Chronic inflammation: A key role in degeneration of bicuspid aortic valve

Salvatore Novo, Giuseppina Novo, Novo, Nobile, Giuseppina Novo, Manno, Morreale, Riccardo Bentivegna, Santangelo, Andrea Santangelo, Domenico Nobile, Girolamo Manno, Pierluigi Morreale, Riccardo Bentivegna

Risultato della ricerca: Article

Abstract

Introduction: Bicuspid aortic valve (BAV) is the most common congenital valvular heart defect resulting from abnormal aortic cusp formation during heart development, where two of the three normal and equal sized cusps fuse into a single large cusp resulting in a two cusps aortic valve. Over the past years, much interest has been given in understanding the pathogenesis of BAV and its complications. In this review, we focused on the role of inflammation, involved in the degeneration of BAV and the development of its complications. Role of inflammation: From a pathophysiological point of view, BAV may rapidly progress into aortic stenosis (AS) and is related to aortopathy. Several histopathologic studies have demonstrated that the development and progression of alterations in bicuspid aortic valve are related to an active process that includes: oxidative stress, shear stress, endothelial dysfunction, disorganized tissue architecture, inflammatory cells and cytokines. These factors are closely related one to each other, constituting the basis of the structural and functional alterations of the BAV. Conclusion: Chronic inflammation plays a key role in the degeneration of BAV. Severe aortic stenosis in bicuspid aortic valves is associated with a more aggressive inflammatory process, increased inflammatory cells infiltration and neovascularization when compared to tricuspid AS. These findings might help to explain the more frequent onset and rapid progression of AS and the heavy aortic valve calcification seen in patients with BAV.
Lingua originaleEnglish
pagine (da-a)59-64
Numero di pagine6
RivistaJournal of Molecular and Cellular Cardiology
Volume130
Stato di pubblicazionePublished - 2019

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Inflammation
Aortic Valve Stenosis
Bicuspid Aortic Valve
Congenital Heart Defects
Aortic Valve
Oxidative Stress
Cytokines

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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Chronic inflammation: A key role in degeneration of bicuspid aortic valve. / Novo, Salvatore; Novo, Giuseppina; Novo; Nobile; Novo, Giuseppina; Manno; Morreale; Bentivegna, Riccardo; Santangelo; Santangelo, Andrea; Nobile, Domenico; Manno, Girolamo; Morreale, Pierluigi; Bentivegna, Riccardo.

In: Journal of Molecular and Cellular Cardiology, Vol. 130, 2019, pag. 59-64.

Risultato della ricerca: Article

Novo, S, Novo, G, Novo, Nobile, Novo, G, Manno, Morreale, Bentivegna, R, Santangelo, Santangelo, A, Nobile, D, Manno, G, Morreale, P & Bentivegna, R 2019, 'Chronic inflammation: A key role in degeneration of bicuspid aortic valve', Journal of Molecular and Cellular Cardiology, vol. 130, pagg. 59-64.
Novo, Salvatore ; Novo, Giuseppina ; Novo ; Nobile ; Novo, Giuseppina ; Manno ; Morreale ; Bentivegna, Riccardo ; Santangelo ; Santangelo, Andrea ; Nobile, Domenico ; Manno, Girolamo ; Morreale, Pierluigi ; Bentivegna, Riccardo. / Chronic inflammation: A key role in degeneration of bicuspid aortic valve. In: Journal of Molecular and Cellular Cardiology. 2019 ; Vol. 130. pagg. 59-64.
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abstract = "Introduction: Bicuspid aortic valve (BAV) is the most common congenital valvular heart defect resulting from abnormal aortic cusp formation during heart development, where two of the three normal and equal sized cusps fuse into a single large cusp resulting in a two cusps aortic valve. Over the past years, much interest has been given in understanding the pathogenesis of BAV and its complications. In this review, we focused on the role of inflammation, involved in the degeneration of BAV and the development of its complications. Role of inflammation: From a pathophysiological point of view, BAV may rapidly progress into aortic stenosis (AS) and is related to aortopathy. Several histopathologic studies have demonstrated that the development and progression of alterations in bicuspid aortic valve are related to an active process that includes: oxidative stress, shear stress, endothelial dysfunction, disorganized tissue architecture, inflammatory cells and cytokines. These factors are closely related one to each other, constituting the basis of the structural and functional alterations of the BAV. Conclusion: Chronic inflammation plays a key role in the degeneration of BAV. Severe aortic stenosis in bicuspid aortic valves is associated with a more aggressive inflammatory process, increased inflammatory cells infiltration and neovascularization when compared to tricuspid AS. These findings might help to explain the more frequent onset and rapid progression of AS and the heavy aortic valve calcification seen in patients with BAV.",
author = "Salvatore Novo and Giuseppina Novo and Novo and Nobile and Giuseppina Novo and Manno and Morreale and Riccardo Bentivegna and Santangelo and Andrea Santangelo and Domenico Nobile and Girolamo Manno and Pierluigi Morreale and Riccardo Bentivegna",
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T1 - Chronic inflammation: A key role in degeneration of bicuspid aortic valve

AU - Novo, Salvatore

AU - Novo, Giuseppina

AU - Novo, null

AU - Nobile, null

AU - Novo, Giuseppina

AU - Manno, null

AU - Morreale, null

AU - Bentivegna, Riccardo

AU - Santangelo, null

AU - Santangelo, Andrea

AU - Nobile, Domenico

AU - Manno, Girolamo

AU - Morreale, Pierluigi

AU - Bentivegna, Riccardo

PY - 2019

Y1 - 2019

N2 - Introduction: Bicuspid aortic valve (BAV) is the most common congenital valvular heart defect resulting from abnormal aortic cusp formation during heart development, where two of the three normal and equal sized cusps fuse into a single large cusp resulting in a two cusps aortic valve. Over the past years, much interest has been given in understanding the pathogenesis of BAV and its complications. In this review, we focused on the role of inflammation, involved in the degeneration of BAV and the development of its complications. Role of inflammation: From a pathophysiological point of view, BAV may rapidly progress into aortic stenosis (AS) and is related to aortopathy. Several histopathologic studies have demonstrated that the development and progression of alterations in bicuspid aortic valve are related to an active process that includes: oxidative stress, shear stress, endothelial dysfunction, disorganized tissue architecture, inflammatory cells and cytokines. These factors are closely related one to each other, constituting the basis of the structural and functional alterations of the BAV. Conclusion: Chronic inflammation plays a key role in the degeneration of BAV. Severe aortic stenosis in bicuspid aortic valves is associated with a more aggressive inflammatory process, increased inflammatory cells infiltration and neovascularization when compared to tricuspid AS. These findings might help to explain the more frequent onset and rapid progression of AS and the heavy aortic valve calcification seen in patients with BAV.

AB - Introduction: Bicuspid aortic valve (BAV) is the most common congenital valvular heart defect resulting from abnormal aortic cusp formation during heart development, where two of the three normal and equal sized cusps fuse into a single large cusp resulting in a two cusps aortic valve. Over the past years, much interest has been given in understanding the pathogenesis of BAV and its complications. In this review, we focused on the role of inflammation, involved in the degeneration of BAV and the development of its complications. Role of inflammation: From a pathophysiological point of view, BAV may rapidly progress into aortic stenosis (AS) and is related to aortopathy. Several histopathologic studies have demonstrated that the development and progression of alterations in bicuspid aortic valve are related to an active process that includes: oxidative stress, shear stress, endothelial dysfunction, disorganized tissue architecture, inflammatory cells and cytokines. These factors are closely related one to each other, constituting the basis of the structural and functional alterations of the BAV. Conclusion: Chronic inflammation plays a key role in the degeneration of BAV. Severe aortic stenosis in bicuspid aortic valves is associated with a more aggressive inflammatory process, increased inflammatory cells infiltration and neovascularization when compared to tricuspid AS. These findings might help to explain the more frequent onset and rapid progression of AS and the heavy aortic valve calcification seen in patients with BAV.

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