CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

Giorgio Stassi, Simone Di Franco, Gabriele De Luca, Antonella Sistigu, Ilio Vitale, Francesca Sperati, Gwenola Manic, Sara Vitale, Marcello Maugeri-Saccà, Sabina Barresi, Matteo Pallocca, Silvia Siteni, Carla Azzurra Amoreo, Eleonora Policicchio, Giorgio Russo, Martina Musella, Francesca Corradi, Marta Baiocchi, Maria Laura De Angelis, Marco TartagliaFrancesca De Nicola, Ann Zeuner, Michele Signore, Marco Tartaglia, Maurizio Fanciulli, Marcella Mottolese, Ruggero De Maria

Risultato della ricerca: Articlepeer review

38 Citazioni (Scopus)

Abstract

Cancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this study was to identify novel CSC-targeting strategies.
Lingua originaleEnglish
pagine (da-a)903-917
Numero di pagine15
RivistaGut
Volume67
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2715???

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