Chitosan-Coating Deposition via Galvanic Coupling

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Abstract

A galvanic method to deposit chitosan coatings on stainless steel substrate is reported. Deposition of suitable coatings is desired to improve biocompatibility and corrosion resistance of metallic medical devices to be implanted in human body. In the present work, a thin hydrogel layer of chitosan was deposited on 304SS by a galvanic displacement reaction, which is advantageous first as it does not require external power supply. 304SS was immersed into an aqueous solution of chitosan/lactic acid and electrochemically coupled with magnesium acting as a sacrificial anode. SEM images showed the formation of a uniform layer of chitosan with a thickness controlled by deposition time. Corrosion tests in simulating body fluid showed that chitosan coatings shift the corrosion potential of 304 substrates toward nobler values. Finally, the cytotoxicity of the coating was investigated through cell viability assays with osteoblastic cell MC3T3-E1. The results revealed highly satisfying biocompatibility of the coating.
Lingua originaleEnglish
pagine (da-a)1715-1724
Numero di pagine10
RivistaACS BIOMATERIALS SCIENCE & ENGINEERING
Volume5
Stato di pubblicazionePublished - 2019

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Chitosan
Coatings
Biocompatibility
Corrosion
Hydrogel
Body fluids
Stainless Steel
Substrates
Lactic acid
Cytotoxicity
Hydrogels
Magnesium
Corrosion resistance
Lactic Acid
Assays
Anodes
Deposits
Stainless steel
Cells
Scanning electron microscopy

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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title = "Chitosan-Coating Deposition via Galvanic Coupling",
abstract = "A galvanic method to deposit chitosan coatings on stainless steel substrate is reported. Deposition of suitable coatings is desired to improve biocompatibility and corrosion resistance of metallic medical devices to be implanted in human body. In the present work, a thin hydrogel layer of chitosan was deposited on 304SS by a galvanic displacement reaction, which is advantageous first as it does not require external power supply. 304SS was immersed into an aqueous solution of chitosan/lactic acid and electrochemically coupled with magnesium acting as a sacrificial anode. SEM images showed the formation of a uniform layer of chitosan with a thickness controlled by deposition time. Corrosion tests in simulating body fluid showed that chitosan coatings shift the corrosion potential of 304 substrates toward nobler values. Finally, the cytotoxicity of the coating was investigated through cell viability assays with osteoblastic cell MC3T3-E1. The results revealed highly satisfying biocompatibility of the coating.",
keywords = "304SS stainless steel, Biomaterials, Biomedical Engineering, biocoatings, chitosan, cytotoxicity, galvanic deposition, medical devices biomaterial",
author = "{Carfi' Pavia}, Francesco and Carmelo Sunseri and {La Carrubba}, Vincenzo and Gioacchino Conoscenti and Brucato, {Valerio Maria Bartolo} and Salvatore Piazza and Rosalinda Inguanta and Gioacchino Conoscenti and {La Carrubba}, Vincenzo and Valerio Brucato and Giuseppe Blanda",
year = "2019",
language = "English",
volume = "5",
pages = "1715--1724",
journal = "ACS BIOMATERIALS SCIENCE & ENGINEERING",
issn = "2373-9878",

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TY - JOUR

T1 - Chitosan-Coating Deposition via Galvanic Coupling

AU - Carfi' Pavia, Francesco

AU - Sunseri, Carmelo

AU - La Carrubba, Vincenzo

AU - Conoscenti, Gioacchino

AU - Brucato, Valerio Maria Bartolo

AU - Piazza, Salvatore

AU - Inguanta, Rosalinda

AU - Conoscenti, Gioacchino

AU - La Carrubba, Vincenzo

AU - Brucato, Valerio

AU - Blanda, Giuseppe

PY - 2019

Y1 - 2019

N2 - A galvanic method to deposit chitosan coatings on stainless steel substrate is reported. Deposition of suitable coatings is desired to improve biocompatibility and corrosion resistance of metallic medical devices to be implanted in human body. In the present work, a thin hydrogel layer of chitosan was deposited on 304SS by a galvanic displacement reaction, which is advantageous first as it does not require external power supply. 304SS was immersed into an aqueous solution of chitosan/lactic acid and electrochemically coupled with magnesium acting as a sacrificial anode. SEM images showed the formation of a uniform layer of chitosan with a thickness controlled by deposition time. Corrosion tests in simulating body fluid showed that chitosan coatings shift the corrosion potential of 304 substrates toward nobler values. Finally, the cytotoxicity of the coating was investigated through cell viability assays with osteoblastic cell MC3T3-E1. The results revealed highly satisfying biocompatibility of the coating.

AB - A galvanic method to deposit chitosan coatings on stainless steel substrate is reported. Deposition of suitable coatings is desired to improve biocompatibility and corrosion resistance of metallic medical devices to be implanted in human body. In the present work, a thin hydrogel layer of chitosan was deposited on 304SS by a galvanic displacement reaction, which is advantageous first as it does not require external power supply. 304SS was immersed into an aqueous solution of chitosan/lactic acid and electrochemically coupled with magnesium acting as a sacrificial anode. SEM images showed the formation of a uniform layer of chitosan with a thickness controlled by deposition time. Corrosion tests in simulating body fluid showed that chitosan coatings shift the corrosion potential of 304 substrates toward nobler values. Finally, the cytotoxicity of the coating was investigated through cell viability assays with osteoblastic cell MC3T3-E1. The results revealed highly satisfying biocompatibility of the coating.

KW - 304SS stainless steel

KW - Biomaterials

KW - Biomedical Engineering

KW - biocoatings

KW - chitosan

KW - cytotoxicity

KW - galvanic deposition

KW - medical devices biomaterial

UR - http://hdl.handle.net/10447/352962

UR - http://pubs.acs.org/journal/abseba

M3 - Article

VL - 5

SP - 1715

EP - 1724

JO - ACS BIOMATERIALS SCIENCE & ENGINEERING

JF - ACS BIOMATERIALS SCIENCE & ENGINEERING

SN - 2373-9878

ER -