Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003⁻2012) of Epidemiological Surveillance

Francesco Vitale, Walter Mazzucco, Rosanna Cusimano, Paolo D’Angelo, Giuseppa Rudisi, Claudia Marotta, Giorgio Graziano, Giuseppa Rudisi, Maurizio Zarcone, Paolo D'Angelo, Rosanna Cusimano, Sergio Mazzola

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

Italy has one of the highest paediatric cancer incidence rates in Europe. We compared cancer incidence and survival rates in children (0⁻14 years) and adolescents (15⁻19 years) residing in Palermo Province (PP) with statistics derived from Italian and European surveillance systems. We included all incident cancer cases, malignant tumours and non-malignant neoplasm of central nervous system (benign and uncertain whether malignant or benign), detected in children and adolescents by the Palermo Province Cancer Registry (PPCR) between 2003 and 2012. A jointpoint regression model was applied. Annual Average Percentage Changes were calculated. The Besag⁻York-Mollie model was used to detect any cluster. The 5-year survival analysis was computed using Kaplan-Meier and actuarial methods. We identified 555 paediatric cancer incident cases (90% “malignant tumours”). No difference in incidence rates was highlighted between PPCR and Italy 26 registries and between PPCR and Southern Europe. No jointpoint or significant trend was identified and no cluster was detected. The 5-year overall survival didn’t differ between PP and the Italian AIRTUM pool. A borderline higher statistically significant survival was observed in age-group 1⁻4 when comparing PPCR to EUROCARE-5. The epidemiological surveillance documented in the PP was a paediatric cancer burden in line with Italy and southern Europe. The study supports the supplementary role of general population-based cancer registries to provide paediatric cancer surveillance of local communities.
Lingua originaleEnglish
pagine (da-a)1344-
Numero di pagine14
RivistaDefault journal
Volume15
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cita questo

Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003⁻2012) of Epidemiological Surveillance. / Vitale, Francesco; Mazzucco, Walter; Cusimano, Rosanna; D’Angelo, Paolo; Rudisi, Giuseppa; Marotta, Claudia; Graziano, Giorgio; Rudisi, Giuseppa; Zarcone, Maurizio; D'Angelo, Paolo; Cusimano, Rosanna; Mazzola, Sergio.

In: Default journal, Vol. 15, 2018, pag. 1344-.

Risultato della ricerca: Article

Vitale, F, Mazzucco, W, Cusimano, R, D’Angelo, P, Rudisi, G, Marotta, C, Graziano, G, Rudisi, G, Zarcone, M, D'Angelo, P, Cusimano, R & Mazzola, S 2018, 'Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003⁻2012) of Epidemiological Surveillance', Default journal, vol. 15, pagg. 1344-.
Vitale, Francesco ; Mazzucco, Walter ; Cusimano, Rosanna ; D’Angelo, Paolo ; Rudisi, Giuseppa ; Marotta, Claudia ; Graziano, Giorgio ; Rudisi, Giuseppa ; Zarcone, Maurizio ; D'Angelo, Paolo ; Cusimano, Rosanna ; Mazzola, Sergio. / Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003⁻2012) of Epidemiological Surveillance. In: Default journal. 2018 ; Vol. 15. pagg. 1344-.
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abstract = "Italy has one of the highest paediatric cancer incidence rates in Europe. We compared cancer incidence and survival rates in children (0⁻14 years) and adolescents (15⁻19 years) residing in Palermo Province (PP) with statistics derived from Italian and European surveillance systems. We included all incident cancer cases, malignant tumours and non-malignant neoplasm of central nervous system (benign and uncertain whether malignant or benign), detected in children and adolescents by the Palermo Province Cancer Registry (PPCR) between 2003 and 2012. A jointpoint regression model was applied. Annual Average Percentage Changes were calculated. The Besag⁻York-Mollie model was used to detect any cluster. The 5-year survival analysis was computed using Kaplan-Meier and actuarial methods. We identified 555 paediatric cancer incident cases (90{\%} “malignant tumours”). No difference in incidence rates was highlighted between PPCR and Italy 26 registries and between PPCR and Southern Europe. No jointpoint or significant trend was identified and no cluster was detected. The 5-year overall survival didn’t differ between PP and the Italian AIRTUM pool. A borderline higher statistically significant survival was observed in age-group 1⁻4 when comparing PPCR to EUROCARE-5. The epidemiological surveillance documented in the PP was a paediatric cancer burden in line with Italy and southern Europe. The study supports the supplementary role of general population-based cancer registries to provide paediatric cancer surveillance of local communities.",
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author = "Francesco Vitale and Walter Mazzucco and Rosanna Cusimano and Paolo D’Angelo and Giuseppa Rudisi and Claudia Marotta and Giorgio Graziano and Giuseppa Rudisi and Maurizio Zarcone and Paolo D'Angelo and Rosanna Cusimano and Sergio Mazzola",
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T1 - Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003⁻2012) of Epidemiological Surveillance

AU - Vitale, Francesco

AU - Mazzucco, Walter

AU - Cusimano, Rosanna

AU - D’Angelo, Paolo

AU - Rudisi, Giuseppa

AU - Marotta, Claudia

AU - Graziano, Giorgio

AU - Rudisi, Giuseppa

AU - Zarcone, Maurizio

AU - D'Angelo, Paolo

AU - Cusimano, Rosanna

AU - Mazzola, Sergio

PY - 2018

Y1 - 2018

N2 - Italy has one of the highest paediatric cancer incidence rates in Europe. We compared cancer incidence and survival rates in children (0⁻14 years) and adolescents (15⁻19 years) residing in Palermo Province (PP) with statistics derived from Italian and European surveillance systems. We included all incident cancer cases, malignant tumours and non-malignant neoplasm of central nervous system (benign and uncertain whether malignant or benign), detected in children and adolescents by the Palermo Province Cancer Registry (PPCR) between 2003 and 2012. A jointpoint regression model was applied. Annual Average Percentage Changes were calculated. The Besag⁻York-Mollie model was used to detect any cluster. The 5-year survival analysis was computed using Kaplan-Meier and actuarial methods. We identified 555 paediatric cancer incident cases (90% “malignant tumours”). No difference in incidence rates was highlighted between PPCR and Italy 26 registries and between PPCR and Southern Europe. No jointpoint or significant trend was identified and no cluster was detected. The 5-year overall survival didn’t differ between PP and the Italian AIRTUM pool. A borderline higher statistically significant survival was observed in age-group 1⁻4 when comparing PPCR to EUROCARE-5. The epidemiological surveillance documented in the PP was a paediatric cancer burden in line with Italy and southern Europe. The study supports the supplementary role of general population-based cancer registries to provide paediatric cancer surveillance of local communities.

AB - Italy has one of the highest paediatric cancer incidence rates in Europe. We compared cancer incidence and survival rates in children (0⁻14 years) and adolescents (15⁻19 years) residing in Palermo Province (PP) with statistics derived from Italian and European surveillance systems. We included all incident cancer cases, malignant tumours and non-malignant neoplasm of central nervous system (benign and uncertain whether malignant or benign), detected in children and adolescents by the Palermo Province Cancer Registry (PPCR) between 2003 and 2012. A jointpoint regression model was applied. Annual Average Percentage Changes were calculated. The Besag⁻York-Mollie model was used to detect any cluster. The 5-year survival analysis was computed using Kaplan-Meier and actuarial methods. We identified 555 paediatric cancer incident cases (90% “malignant tumours”). No difference in incidence rates was highlighted between PPCR and Italy 26 registries and between PPCR and Southern Europe. No jointpoint or significant trend was identified and no cluster was detected. The 5-year overall survival didn’t differ between PP and the Italian AIRTUM pool. A borderline higher statistically significant survival was observed in age-group 1⁻4 when comparing PPCR to EUROCARE-5. The epidemiological surveillance documented in the PP was a paediatric cancer burden in line with Italy and southern Europe. The study supports the supplementary role of general population-based cancer registries to provide paediatric cancer surveillance of local communities.

KW - Preschool; Female; Humans; Incidence; Infant; Italy; Male; Neoplasms; Registries; Survival Rate; Young Adult

KW - cancer in childhood and adolescence; cancer incidence; cancer survival; epidemiological surveillance; jointpoint regression; population-based cancer registries; time trends; Adolescent; Child; Child

UR - http://hdl.handle.net/10447/356465

M3 - Article

VL - 15

SP - 1344-

JO - Default journal

JF - Default journal

ER -