Chemotherapy-induced cardiotoxicity: role of the conventional echocardiography and the Tissue Doppler

Giuseppina Novo, Natale D'Alessandro, Salvatore Novo, Angelica Peritore, Daniela Di Lisi, Francesca Bonura, Francesca Macaione, Mariacristina Meschisi

Risultato della ricerca: Article

11 Citazioni (Scopus)

Abstract

Aim. The cardiotoxicity of anticancer drugs is an emerging problem and only an identification of the early signs of cardiotoxicity by conventional echocardiography and not (tissue Doppler imaging, TDI), will limit and contain the long-term cardiotoxicity effects. The aim of this study was to identify, through conventional echocardiography and TDI, parameters to use as early "signs" of cardiotoxicity.Methods. A prospective study was performed using patients with breast cancer (72 women, median age 57+/-12) treated with anticancer drugs (adjuvant chemotherapy). All patients underwent a careful cardiological evaluation before starting treatment (T0) and during follow-up at 3 months (T1), 6 months (T2) and 1 year (T3). Electrocardiography and echocardiography were performed in all patients in these times. Echocardiography evaluation considered the following parameters: systolic and diastolic diameters and volumes, LVEF, MAPSE, TAPSE, E/A TDI (Ern, Am, Sm, IVCT, IVRT, ET, TEI index). On the basis of chemotherapy treatment, patients were divided into 5 groups: A=FEC (fluorouracil, epirubicin, cyclophosphamide), B=FEC+trastuzumab, C=trastuzumab, D=FEC+taxotere, E=FEC+taxolo+trastuzumab.Results. A significant reduction in the echo parameters of TDI was observed. TDI appears to offer important advantages over traditional techniques in revealing the presence of early signs of cardiotoxicity.Conclusion. The TDI should be utilized to complement conventional echocardiography in the assessment of cardiotoxicity
Lingua originaleEnglish
pagine (da-a)301-308
Numero di pagine8
RivistaDefault journal
Volume59
Stato di pubblicazionePublished - 2011

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Doppler Echocardiography
Drug Therapy
Echocardiography
docetaxel
Epirubicin
Adjuvant Chemotherapy
Fluorouracil
Pharmaceutical Preparations
Cyclophosphamide
Cardiotoxicity
Electrocardiography
Prospective Studies
Breast Neoplasms
Therapeutics
Trastuzumab

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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Chemotherapy-induced cardiotoxicity: role of the conventional echocardiography and the Tissue Doppler. / Novo, Giuseppina; D'Alessandro, Natale; Novo, Salvatore; Peritore, Angelica; Di Lisi, Daniela; Bonura, Francesca; Macaione, Francesca; Meschisi, Mariacristina.

In: Default journal, Vol. 59, 2011, pag. 301-308.

Risultato della ricerca: Article

Novo, Giuseppina ; D'Alessandro, Natale ; Novo, Salvatore ; Peritore, Angelica ; Di Lisi, Daniela ; Bonura, Francesca ; Macaione, Francesca ; Meschisi, Mariacristina. / Chemotherapy-induced cardiotoxicity: role of the conventional echocardiography and the Tissue Doppler. In: Default journal. 2011 ; Vol. 59. pagg. 301-308.
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AU - Novo, Giuseppina

AU - D'Alessandro, Natale

AU - Novo, Salvatore

AU - Peritore, Angelica

AU - Di Lisi, Daniela

AU - Bonura, Francesca

AU - Macaione, Francesca

AU - Meschisi, Mariacristina

PY - 2011

Y1 - 2011

N2 - Aim. The cardiotoxicity of anticancer drugs is an emerging problem and only an identification of the early signs of cardiotoxicity by conventional echocardiography and not (tissue Doppler imaging, TDI), will limit and contain the long-term cardiotoxicity effects. The aim of this study was to identify, through conventional echocardiography and TDI, parameters to use as early "signs" of cardiotoxicity.Methods. A prospective study was performed using patients with breast cancer (72 women, median age 57+/-12) treated with anticancer drugs (adjuvant chemotherapy). All patients underwent a careful cardiological evaluation before starting treatment (T0) and during follow-up at 3 months (T1), 6 months (T2) and 1 year (T3). Electrocardiography and echocardiography were performed in all patients in these times. Echocardiography evaluation considered the following parameters: systolic and diastolic diameters and volumes, LVEF, MAPSE, TAPSE, E/A TDI (Ern, Am, Sm, IVCT, IVRT, ET, TEI index). On the basis of chemotherapy treatment, patients were divided into 5 groups: A=FEC (fluorouracil, epirubicin, cyclophosphamide), B=FEC+trastuzumab, C=trastuzumab, D=FEC+taxotere, E=FEC+taxolo+trastuzumab.Results. A significant reduction in the echo parameters of TDI was observed. TDI appears to offer important advantages over traditional techniques in revealing the presence of early signs of cardiotoxicity.Conclusion. The TDI should be utilized to complement conventional echocardiography in the assessment of cardiotoxicity

AB - Aim. The cardiotoxicity of anticancer drugs is an emerging problem and only an identification of the early signs of cardiotoxicity by conventional echocardiography and not (tissue Doppler imaging, TDI), will limit and contain the long-term cardiotoxicity effects. The aim of this study was to identify, through conventional echocardiography and TDI, parameters to use as early "signs" of cardiotoxicity.Methods. A prospective study was performed using patients with breast cancer (72 women, median age 57+/-12) treated with anticancer drugs (adjuvant chemotherapy). All patients underwent a careful cardiological evaluation before starting treatment (T0) and during follow-up at 3 months (T1), 6 months (T2) and 1 year (T3). Electrocardiography and echocardiography were performed in all patients in these times. Echocardiography evaluation considered the following parameters: systolic and diastolic diameters and volumes, LVEF, MAPSE, TAPSE, E/A TDI (Ern, Am, Sm, IVCT, IVRT, ET, TEI index). On the basis of chemotherapy treatment, patients were divided into 5 groups: A=FEC (fluorouracil, epirubicin, cyclophosphamide), B=FEC+trastuzumab, C=trastuzumab, D=FEC+taxotere, E=FEC+taxolo+trastuzumab.Results. A significant reduction in the echo parameters of TDI was observed. TDI appears to offer important advantages over traditional techniques in revealing the presence of early signs of cardiotoxicity.Conclusion. The TDI should be utilized to complement conventional echocardiography in the assessment of cardiotoxicity

KW - cardiotossicità

KW - chemioterapia antitumorale

KW - doppler tissutale

KW - ecocardiogramma

UR - http://hdl.handle.net/10447/56452

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JO - Default journal

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