Abstract

Clay minerals have been used for medical purposes from ancient times. Among them, the halloysite nanotube, an aluminosilicate of the kaolin group, is an emerging nanomaterial which possesses peculiar chemical characteristics. By means of suitable modifications, such as supramolecular functionalization or covalent modifications, it is possible to obtain novel nanomaterials with tunable properties for several applications. In this context the covalent grafting of suitable organic moieties on the external surface or in the halloysite lumen has been exploited to improve the loading and release of several biologically active molecules. The resulting hybrid nanomaterials have been applied as drug carrier and delivery systems, as fillers for hydrogels, in tissue regeneration and in the gene delivery field. Furthermore the loading and release of specific molecules have been also investigated for environmental purposes. This review summarizes the main developments in the halloysite modifications in the last 20 years with a particular attention to the development in the past two years.
Lingua originaleEnglish
pagine (da-a)3415-3433
Numero di pagine19
RivistaJOURNAL OF MATERIALS CHEMISTRY. B
Volume6
Stato di pubblicazionePublished - 2018

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Chemical modification
Nanostructured materials
Nanotubes
Kaolin
Tissue regeneration
Drug Carriers
Molecules
Hydrogels
Aluminosilicates
Clay minerals
Fillers
Genes
clay

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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title = "Chemical modification of halloysite nanotubes forcontrolled loading and release",
abstract = "Clay minerals have been used for medical purposes from ancient times. Among them, the halloysite nanotube, an aluminosilicate of the kaolin group, is an emerging nanomaterial which possesses peculiar chemical characteristics. By means of suitable modifications, such as supramolecular functionalization or covalent modifications, it is possible to obtain novel nanomaterials with tunable properties for several applications. In this context the covalent grafting of suitable organic moieties on the external surface or in the halloysite lumen has been exploited to improve the loading and release of several biologically active molecules. The resulting hybrid nanomaterials have been applied as drug carrier and delivery systems, as fillers for hydrogels, in tissue regeneration and in the gene delivery field. Furthermore the loading and release of specific molecules have been also investigated for environmental purposes. This review summarizes the main developments in the halloysite modifications in the last 20 years with a particular attention to the development in the past two years.",
keywords = "Biologically active molecules; Chemical characteristic; Covalent grafting; Covalent modifications; Functionalizations; Halloysite nanotubes; Hybrid nanomaterials; Tunable properties, Chemical modification; Clay; Gene transfer; Kaolinite; Molecules; Nanostructured materials; Nanotubes; Targeted drug delivery; Tissue regeneration; Yarn, Controlled drug delivery",
author = "Stefana Milioto and Colletti, {Carmelo Giuseppe} and Serena Riela and Giuseppe Lazzara and Giuseppe Cavallaro and Marina Massaro and Renato Noto",
year = "2018",
language = "English",
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AU - Milioto, Stefana

AU - Colletti, Carmelo Giuseppe

AU - Riela, Serena

AU - Lazzara, Giuseppe

AU - Cavallaro, Giuseppe

AU - Massaro, Marina

AU - Noto, Renato

PY - 2018

Y1 - 2018

N2 - Clay minerals have been used for medical purposes from ancient times. Among them, the halloysite nanotube, an aluminosilicate of the kaolin group, is an emerging nanomaterial which possesses peculiar chemical characteristics. By means of suitable modifications, such as supramolecular functionalization or covalent modifications, it is possible to obtain novel nanomaterials with tunable properties for several applications. In this context the covalent grafting of suitable organic moieties on the external surface or in the halloysite lumen has been exploited to improve the loading and release of several biologically active molecules. The resulting hybrid nanomaterials have been applied as drug carrier and delivery systems, as fillers for hydrogels, in tissue regeneration and in the gene delivery field. Furthermore the loading and release of specific molecules have been also investigated for environmental purposes. This review summarizes the main developments in the halloysite modifications in the last 20 years with a particular attention to the development in the past two years.

AB - Clay minerals have been used for medical purposes from ancient times. Among them, the halloysite nanotube, an aluminosilicate of the kaolin group, is an emerging nanomaterial which possesses peculiar chemical characteristics. By means of suitable modifications, such as supramolecular functionalization or covalent modifications, it is possible to obtain novel nanomaterials with tunable properties for several applications. In this context the covalent grafting of suitable organic moieties on the external surface or in the halloysite lumen has been exploited to improve the loading and release of several biologically active molecules. The resulting hybrid nanomaterials have been applied as drug carrier and delivery systems, as fillers for hydrogels, in tissue regeneration and in the gene delivery field. Furthermore the loading and release of specific molecules have been also investigated for environmental purposes. This review summarizes the main developments in the halloysite modifications in the last 20 years with a particular attention to the development in the past two years.

KW - Biologically active molecules; Chemical characteristic; Covalent grafting; Covalent modifications; Functionalizations; Halloysite nanotubes; Hybrid nanomaterials; Tunable properties

KW - Chemical modification; Clay; Gene transfer; Kaolinite; Molecules; Nanostructured materials; Nanotubes; Targeted drug delivery; Tissue regeneration; Yarn

KW - Controlled drug delivery

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JO - JOURNAL OF MATERIALS CHEMISTRY. B

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