Characterization of metabolically healthy obese people and metabolically unhealthy normal-weight people in a general population cohort of the ABCD Study

Carla Giordano, Maria Fatima Massenti, Silvio Buscemi, Carla Giordano, Vincenza Maniaci, Anna Maria Barile, Giuseppe Rosafio, Loretta Cosentino, Valentina Settipani, Carola Buscemi, Davide Corleo, Pierfilippo Chiarello, Silvio Buscemi, Davide Corleo

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age 18-90 years) of the cohort of the ABCD-2 study were investigated. Participants were classified as normal weight (BMI < 24.9 kg/m2) or overweight-obese (BMI â¥25 kg/m2); they were also classified as MH in the presence of 0-1 among the following conditions: (a) prediabetes/type 2 diabetes, (b) hypertension, (c) hypertriglyceridemia or low HDL cholesterolemia, and (d) hypercholesterolemia. MUH condition was diagnosed if â¥2 of the conditions listed were found. The prevalence of overweight/obese people was 71.1%, of whom 27.4% were found to be MH. In addition, 36.7% of the normal-weight participants were MUH. HOMA-IR, high sensitivity C-reactive protein, and the carotid intima-media thickness were significantly different in the 4 subgroups (P < 0.001), with higher values observed in the MUH normal-weight and obese groups. In conclusion, this study highlights the importance of identifying a MH condition in normal-weight and in obese people in order to offer better treatment.
Lingua originaleEnglish
pagine (da-a)1-9
Numero di pagine9
RivistaDefault journal
Volume2017
Stato di pubblicazionePublished - 2017

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Cohort Studies
Weights and Measures
Population
Prediabetic State
Carotid Intima-Media Thickness
Hypertriglyceridemia
Hypercholesterolemia
C-Reactive Protein
Type 2 Diabetes Mellitus
Obesity
Hypertension

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cita questo

Characterization of metabolically healthy obese people and metabolically unhealthy normal-weight people in a general population cohort of the ABCD Study. / Giordano, Carla; Massenti, Maria Fatima; Buscemi, Silvio; Giordano, Carla; Maniaci, Vincenza; Barile, Anna Maria; Rosafio, Giuseppe; Cosentino, Loretta; Settipani, Valentina; Buscemi, Carola; Corleo, Davide; Chiarello, Pierfilippo; Buscemi, Silvio; Corleo, Davide.

In: Default journal, Vol. 2017, 2017, pag. 1-9.

Risultato della ricerca: Article

Giordano, C, Massenti, MF, Buscemi, S, Giordano, C, Maniaci, V, Barile, AM, Rosafio, G, Cosentino, L, Settipani, V, Buscemi, C, Corleo, D, Chiarello, P, Buscemi, S & Corleo, D 2017, 'Characterization of metabolically healthy obese people and metabolically unhealthy normal-weight people in a general population cohort of the ABCD Study', Default journal, vol. 2017, pagg. 1-9.
Giordano, Carla ; Massenti, Maria Fatima ; Buscemi, Silvio ; Giordano, Carla ; Maniaci, Vincenza ; Barile, Anna Maria ; Rosafio, Giuseppe ; Cosentino, Loretta ; Settipani, Valentina ; Buscemi, Carola ; Corleo, Davide ; Chiarello, Pierfilippo ; Buscemi, Silvio ; Corleo, Davide. / Characterization of metabolically healthy obese people and metabolically unhealthy normal-weight people in a general population cohort of the ABCD Study. In: Default journal. 2017 ; Vol. 2017. pagg. 1-9.
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abstract = "There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age 18-90 years) of the cohort of the ABCD-2 study were investigated. Participants were classified as normal weight (BMI < 24.9 kg/m2) or overweight-obese (BMI {\^a}¥25 kg/m2); they were also classified as MH in the presence of 0-1 among the following conditions: (a) prediabetes/type 2 diabetes, (b) hypertension, (c) hypertriglyceridemia or low HDL cholesterolemia, and (d) hypercholesterolemia. MUH condition was diagnosed if {\^a}¥2 of the conditions listed were found. The prevalence of overweight/obese people was 71.1{\%}, of whom 27.4{\%} were found to be MH. In addition, 36.7{\%} of the normal-weight participants were MUH. HOMA-IR, high sensitivity C-reactive protein, and the carotid intima-media thickness were significantly different in the 4 subgroups (P < 0.001), with higher values observed in the MUH normal-weight and obese groups. In conclusion, this study highlights the importance of identifying a MH condition in normal-weight and in obese people in order to offer better treatment.",
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AU - Giordano, Carla

AU - Massenti, Maria Fatima

AU - Buscemi, Silvio

AU - Giordano, Carla

AU - Maniaci, Vincenza

AU - Barile, Anna Maria

AU - Rosafio, Giuseppe

AU - Cosentino, Loretta

AU - Settipani, Valentina

AU - Buscemi, Carola

AU - Corleo, Davide

AU - Chiarello, Pierfilippo

AU - Buscemi, Silvio

AU - Corleo, Davide

PY - 2017

Y1 - 2017

N2 - There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age 18-90 years) of the cohort of the ABCD-2 study were investigated. Participants were classified as normal weight (BMI < 24.9 kg/m2) or overweight-obese (BMI â¥25 kg/m2); they were also classified as MH in the presence of 0-1 among the following conditions: (a) prediabetes/type 2 diabetes, (b) hypertension, (c) hypertriglyceridemia or low HDL cholesterolemia, and (d) hypercholesterolemia. MUH condition was diagnosed if â¥2 of the conditions listed were found. The prevalence of overweight/obese people was 71.1%, of whom 27.4% were found to be MH. In addition, 36.7% of the normal-weight participants were MUH. HOMA-IR, high sensitivity C-reactive protein, and the carotid intima-media thickness were significantly different in the 4 subgroups (P < 0.001), with higher values observed in the MUH normal-weight and obese groups. In conclusion, this study highlights the importance of identifying a MH condition in normal-weight and in obese people in order to offer better treatment.

AB - There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age 18-90 years) of the cohort of the ABCD-2 study were investigated. Participants were classified as normal weight (BMI < 24.9 kg/m2) or overweight-obese (BMI â¥25 kg/m2); they were also classified as MH in the presence of 0-1 among the following conditions: (a) prediabetes/type 2 diabetes, (b) hypertension, (c) hypertriglyceridemia or low HDL cholesterolemia, and (d) hypercholesterolemia. MUH condition was diagnosed if â¥2 of the conditions listed were found. The prevalence of overweight/obese people was 71.1%, of whom 27.4% were found to be MH. In addition, 36.7% of the normal-weight participants were MUH. HOMA-IR, high sensitivity C-reactive protein, and the carotid intima-media thickness were significantly different in the 4 subgroups (P < 0.001), with higher values observed in the MUH normal-weight and obese groups. In conclusion, this study highlights the importance of identifying a MH condition in normal-weight and in obese people in order to offer better treatment.

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