Characterization of human infiltrating and circulating gamma-delta t cells in prostate cancer

Serena Meraviglia, Alchiede Simonato, Daniela Coniglio, Vincenzo Serretta, Marco Vella, Elena Lo Presti, Cristina Scalici Gesolfo, Alberto Abrate, Alchiede Simonato, Marco Vella, Vincenzo Serretta, Alberto Abrate, Cristina Scalici Gesolfo

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa.
Lingua originaleEnglish
pagine (da-a)91-98
Numero di pagine8
RivistaInvestigative and Clinical Urology
Volume60
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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