TY - JOUR
T1 - Characteristics and Changes over Time of Alcohol-Related Chronic Liver Diseases in Italy
AU - Almasio, Pier Luigi
AU - Pisaturo, Mariantonietta
AU - Stroffolini, Tommaso
AU - Furlan, Caterina
AU - Babudieri, Sergio
AU - Sagnelli, Caterina
AU - Babudieri, Sergio
AU - Morisco, Filomena
AU - Russello, Maurizio
AU - Pirisi, Mario
AU - Sagnelli, Evangelista
AU - Stroffolini, Tommaso
AU - Smedile, Antonina
PY - 2018
Y1 - 2018
N2 - Introduction: To evaluate the characteristics of alcohol-related chronic liver disease (CLD) in Italy and their potential changes over time.Patients and Methods: Subjects with CLD were enrolled in two national surveys performed in 2001 and in 2014 in Italy. The two surveys prospectively recruited patients aged ≥ 18 years referring to more than 80 Italian liver units scattered all over the country using similar clinical approach, analytical methods, and threshold of risky alcohol intake definition (≥ 3 units/day in men and ≥ 2 units/day in women).Results: Out of 12,256 enrolled subjects, 2,717 (22.2%) reported a risky alcohol intake. Of them, anti-HCV positive was observed in 48.3% of subjects. The overall sex ratio (M/F) was 3.1, decreasing from 3.8 in 2001 to 1.3 in 2014. Women were significantly older than men (58.9 versus 53.1 years; p < 0.01) and an increasing ageing over time was observed in both sexes. The proportion of subjects with liver cirrhosis increased over time in both sexes, and decompensated stage (Child B or C) was detected in 55.9% of cases in 2001 and 46.0% in 2014.Conclusions: Risky alcohol intake plays a role in more than one-fifth of CLD in Italy, with a shift over time towards an older age and a more severe liver disease stage. These data put alcohol back in the spotlight with an important role in CLD in the years to come in Italy.
AB - Introduction: To evaluate the characteristics of alcohol-related chronic liver disease (CLD) in Italy and their potential changes over time.Patients and Methods: Subjects with CLD were enrolled in two national surveys performed in 2001 and in 2014 in Italy. The two surveys prospectively recruited patients aged ≥ 18 years referring to more than 80 Italian liver units scattered all over the country using similar clinical approach, analytical methods, and threshold of risky alcohol intake definition (≥ 3 units/day in men and ≥ 2 units/day in women).Results: Out of 12,256 enrolled subjects, 2,717 (22.2%) reported a risky alcohol intake. Of them, anti-HCV positive was observed in 48.3% of subjects. The overall sex ratio (M/F) was 3.1, decreasing from 3.8 in 2001 to 1.3 in 2014. Women were significantly older than men (58.9 versus 53.1 years; p < 0.01) and an increasing ageing over time was observed in both sexes. The proportion of subjects with liver cirrhosis increased over time in both sexes, and decompensated stage (Child B or C) was detected in 55.9% of cases in 2001 and 46.0% in 2014.Conclusions: Risky alcohol intake plays a role in more than one-fifth of CLD in Italy, with a shift over time towards an older age and a more severe liver disease stage. These data put alcohol back in the spotlight with an important role in CLD in the years to come in Italy.
UR - http://hdl.handle.net/10447/344408
UR - https://www.hindawi.com/journals/cjgh/2018/9151820/
M3 - Book/Film/Article review
VL - 2018
JO - CANADIAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
JF - CANADIAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
SN - 2291-2789
ER -