TY - JOUR
T1 - Chaperonology: The third eye on brain gliomas
AU - Graziano, Francesca
AU - Campanella, Claudia
AU - Caruso Bavisotto, Celeste
AU - Rappa, Francesca
AU - Cappello, Francesco
AU - Iacopino, Domenico
AU - Marino Gammazza, Antonella
AU - Campanella, Claudia
AU - Gammazza, A. Marino
AU - Rappa, Francesca
AU - Bavisotto, C. Caruso
AU - De Macario, Everly Conway
AU - Cappello, Francesco
AU - De Macario, Everly Conway
AU - Macario, Albert J. L.
PY - 2018
Y1 - 2018
N2 - The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents.
AB - The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents.
UR - http://hdl.handle.net/10447/295724
UR - http://www.mdpi.com/2076-3425/8/6/110/pdf
M3 - Article
VL - 8
SP - 110-
JO - Brain Sciences
JF - Brain Sciences
SN - 2076-3425
ER -