The authors explored cross-sectional associationsbetween MRI parameters (lesion metrics, brainvolumes, magnetization transfer ratio histograms,and metabolite concentrations) and cognition in 61patients who experienced clinically-isolatedsyndromes (CIS) 7 years earlier. IQ decline andpoorer overall cognition were associated with T2white-matter lesions, and slow informationprocessingwith both T2 lesions and gray-matteratrophy. In a previous study of the same cohort,gray-matter atrophy measured shortly after CISfailed to predict development of cognitiveimpairment years later. Our findings suggest thatgray-matter pathology, reflected by atrophymeasurements, becomes increasingly important indetermining cognition as MS progresses.
|Numero di pagine||7|
|Rivista||THE JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES|
|Stato di pubblicazione||Published - 2013|
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Psychiatry and Mental health