Changing associations between cognitive impairment and imaging in multiple sclerosis as the disease progresses.

Lisa Cipolotti, Josephine K. Swanton, Mary M. Summers, David H. Miller, Sophia A. Penny, Lisa Cipolotti, Maria A. Ron

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

The authors explored cross-sectional associationsbetween MRI parameters (lesion metrics, brainvolumes, magnetization transfer ratio histograms,and metabolite concentrations) and cognition in 61patients who experienced clinically-isolatedsyndromes (CIS) 7 years earlier. IQ decline andpoorer overall cognition were associated with T2white-matter lesions, and slow informationprocessingwith both T2 lesions and gray-matteratrophy. In a previous study of the same cohort,gray-matter atrophy measured shortly after CISfailed to predict development of cognitiveimpairment years later. Our findings suggest thatgray-matter pathology, reflected by atrophymeasurements, becomes increasingly important indetermining cognition as MS progresses.
Lingua originaleEnglish
pagine (da-a)134-140
Numero di pagine7
RivistaTHE JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume25
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health

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