Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Maria Rosaria Bonsignore, Pataka, Ulla Anttalainen, Mehmet S. Tasbakan, Gabriel Roisman, Parati, Jean-Louis Pepin, Mcnicholas, Sliwinski, Sofia Schiza, Varoneckas, Ding Zou, Ryan, John A. Kvamme, Steiropoulos, Bielicki, Tkacova, Pierre Escourrou, Ryan, Ferran BarbéSchulz, Jean Lois Pépin, Petiet, Ulla Antalainen, Vitols, Josep M. Montserrat, Penzel, Parati, Varoneckas, Ryan, Gianfranco Parati, Oreste Marrone, Ryan, Riha, Staats, Pretl, Dogas, Plywaczewski, Saaresranta, Johan Verbraecken, Masa, Marrone, Fietze, Jan Hedner, Penzel, Ludger Grote, Barbé, Carolina Lombardi, Holger Hein, Hein, Levy, Ozen K. Basoglu, Joppa, Silke Ryan

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)


The effect of positive airway pressure treatment on weight and markers of centralobesity in patients with obstructive sleep apnea remains unclear. We studied thechange in body weight and anthropometric measures following positive airway pressuretreatment in a large clinical cohort. Patients with obstructive sleep apnea withpositive airway pressure treatment from the European Sleep Apnea Database registry(n = 1,415, 77% male, age 54 11 [mean SD] years, body mass index31.7 6.4 kg/m2, apnea–hypopnea index 37 24 n per hr, Epworth SleepinessScale 10.2 5.0) were selected. Changes in body mass index and neck/waist/hipcircumferences at baseline and at follow-up visit were analysed. Overall, body massindex (0.0 [95% confidence interval, 0.1 to 0.2] kg/m2) and neck circumference(0.0 (95% confidence interval, 0.1 to 0.1] cm) were unchanged after positive airwaypressure treatment compared with baseline (follow-up duration 1.1 1.0 yearsand compliance 5.2 2.1 hr per day). However, in non-obese (body mass index<30 kg/m2) patients, positive airway pressure treatment was associated with anincreased body mass index and waist circumference (0.4 [0.3–0.5] kg/m2 and 0.8[0.4–1.2] cm, respectively, all p < 0.05), and weight gain was significantly associatedwith higher positive airway pressure compliance and longer positive airway pressure treatment duration. In the obese subgroup, body mass index was reduced after positiveairway pressure treatment (0.3 [0.5 to 0.1] kg/m2, p < 0.05) mainly inpatients with a strong reduction in Epworth Sleepiness Scale. In conclusion, positiveairway pressure therapy was not found to systematically change body mass index inthe European Sleep Apnea Database cohort, but the response was heterogeneous.Our findings suggest that weight gain may be restricted to an obstructive sleepapnea phenotype without established obesity. Lifestyle intervention needs to beconsidered in both lean and obese patients with obstructive sleep apnea receivingpositive airway pressure treatment
Lingua originaleEnglish
Numero di pagine10
RivistaJournal of Sleep Research
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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