TY - JOUR
T1 - Challenges and perspectives in obstructive sleep apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society
AU - Bonsignore, Maria Rosaria
AU - Pizza, Fabio
AU - Pepin, Jean-Louis
AU - Mcnicholas, Walter T.
AU - Martinez-Garcia, Miguel-Angel
AU - Montserrat, Josep
AU - Riha, Renata
AU - Ferini-Strambi, Luigi
AU - Riha, Renata
AU - Mihaicuta, Stefan
AU - Pevernagie, Dirk
AU - Verbraecken, Johan
AU - Polo, Olli
AU - Randerath, Winfried
AU - Bassetti, Claudio L.
AU - Hedner, Jan
AU - Farre, Ramon
AU - Ferini-Strambi, Luigi
AU - Grote, Ludger
AU - Kohler, Malcolm
AU - Ryan, Silke
PY - 2018
Y1 - 2018
N2 - Obstructive sleep apnoea (OSA) is a major challenge for physicians and healthcare systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating comorbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications and optimal treatment of patients with OSA.The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes and relevant comorbidities (e.g. nondipping nocturnal blood pressure). Furthermore, current severity thresholds require revision to reflect factors such as the disparity in the apnoea-hypopnoea index (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond AHI.
AB - Obstructive sleep apnoea (OSA) is a major challenge for physicians and healthcare systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating comorbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications and optimal treatment of patients with OSA.The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes and relevant comorbidities (e.g. nondipping nocturnal blood pressure). Furthermore, current severity thresholds require revision to reflect factors such as the disparity in the apnoea-hypopnoea index (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond AHI.
UR - http://hdl.handle.net/10447/358002
M3 - Article
VL - 52
JO - European Respiratory Journal
JF - European Respiratory Journal
SN - 0903-1936
ER -