Challenges and new prospects in hepatosplenic γδ T-celllymphoma.

Alessandro Gulino, Carla Guarnotta, Giovanni Franco, Ada Maria Florena, Vito Franco, Carla Guarnotta, Ada Maria Florena, Marco Calvaruso, Salvatore Buffa, Alessandro Gulino, Maria Grazia Bonura, Matilde Cacciatore, Vito Franco

Risultato della ricerca: Articlepeer review

12 Citazioni (Scopus)

Abstract

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid neoplasms characterized by aggressive clinical behavior and dismal prognosis. Hepatosplenic γδ T-cell lymphoma (γδ-HSTL) is a particular form of PTCL that arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. γδ-HSTL has a rapidly progressive course and poor outcome due also to its refractoriness to conventional chemotherapy regimens. The very low incidence of γδ-HSTL, along with its propensity to mimic different pathological entities, makes this lymphoma a true diagnostic challenge. In this review, we highlight the biological and clinical features of γδ-HSTL that contribute to making this lymphoma a mostly incurable disease. Moreover, we provide a new insight into the crosstalk between HSTL clones and the bone marrow, liver and spleen vascular microenvironment, in which neoplastic cells reside and proliferate. We further discuss γδ-HSTL associated molecules that might be proposed as potential targets for novel therapeutic approaches.
Lingua originaleEnglish
pagine (da-a)1-9
Numero di pagine9
RivistaLEUKEMIA & LYMPHOMA
Volume10
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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