Central obesity and hypertension: the role of plasma endothelin. Am J Hypertens

Rosario Scaglione, Anna Licata, Salvatore Corrao, Antonio Pinto, Giuseppe Licata, Gaspare Parrinello, Giuseppe Licata, Antonio Pinto, Anna Licata, Mariagrazia Cecala, Grazia Di Silvestre, Salvatore Corrao, Gaspare Parrinello, Pietra Amato, Rosario Scaglione

Risultato della ricerca: Articlepeer review

54 Citazioni (Scopus)

Abstract

Hypertension and central obesity are two conditions closely linked, but the mechanisms responsible for obesity-associated hypertension are still unclear. In the last few years, several studies addressed the role of endothelin-1 (ET-1) in the development and maintenance of hypertension. This study was designed to evaluate plasma ET-1 in normotensive and hypertensive central obese subjects compared with a lean healthy group. Our final goal was to analyze the relationship between plasma ET-1, blood pressure, and left ventricular structure and function in central obese subjects (both normotensives and hypertensives). ET-levels have been assessed by the radioimmunoassay method in 20 lean normotensives and in 57 central obese subjects; 30 of them were hypertensives and 27 of them were normotensives. Twenty-four-hour mean blood pressure (MBP/24 h) by noninvasive ambulatory blood pressure monitoring, left ventricular mass/ height (LVM/H), and left ventricular ejection fraction (LVEF) by echocardiography and peak filling rate (PFR) by radionuclide study were also measured. ET levels were significantly (P < .05) higher in obese hypertensives and obese normotensives than in lean normotensives. In addition, ET levels were significantly (P < .05) higher in obese hypertensives than in obese normotensives. ET were directly related to LVM/ H (r = 0.86; P < .001) and MBP/24 h (r = 0.48; P < .009) but only in obese hypertensives. Multiple regression analysis indicated that ET-1 plasma levels remain an independent predictor of MBP/ 24 h and LVM/H also when age was included in the analysis. These data suggest that obesity-associated hypertension is characterized by an endothelial dysfunction that may contribute to the higher cardiovascular risk detectable in these patients.
Lingua originaleEnglish
pagine (da-a)1186-1191
Numero di pagine6
RivistaAmerican Journal of Hypertension
Volume9
Stato di pubblicazionePublished - 1996

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2724???

Fingerprint

Entra nei temi di ricerca di 'Central obesity and hypertension: the role of plasma endothelin. Am J Hypertens'. Insieme formano una fingerprint unica.

Cita questo