Centenarians as a model to discover genetic and epigenetic signatures of healthy ageing

Calogero Caruso, Giulia Accardi, Annibale Alessandro Puca, Francesco Villa, Chiara Spinelli

    Risultato della ricerca: Articlepeer review

    19 Citazioni (Scopus)

    Abstract

    Centenarians are a model of successful ageing. The data favours the theory that, in order to live to 100, it is mandatory to inherit the right genetic variants from parents or acquire epigenetic variants through the environment. Therefore, the study of epigenetic signatures of healthy ageing is becoming an important aspect to identify the role of chromatin modification in ageing and understand how manage this fine-tuning system. So, according to the concept of developmental plasticity, establishment of a longevity phenotype requires a combination of stochastic and non-stochastic events that modulate the genetic substrate and leads to a different outcome. It can be concluded that centenarians have a more powerful "engine" shaped by evolution, and that the environment, through epigenetic system, is a component influencing outcome.
    Lingua originaleEnglish
    pagine (da-a)-
    Numero di pagine8
    RivistaMechanisms of Ageing and Development
    Volume[Epub ahead of print]
    Stato di pubblicazionePublished - 2017

    All Science Journal Classification (ASJC) codes

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    • ???subjectarea.asjc.1300.1309???

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