Cellular and molecular bases of biomineralization in sea urchin embryos

Chiara Martino, Annalisa Pinsino, Konstantinos Karakostis, Francesca Zito, Chiara Martino, Rosa Bonaventura, Valeria Matranga, Roberta Russo, Caterina Costa

Risultato della ricerca: Articlepeer review

11 Citazioni (Scopus)

Abstract

Sea urchin embryos construct their skeleton following a precise gene-regulated time- and space-dependentprogramme, in concert with factors promoting cell adhesion and differentiation. The biomineral is deposited in a privileged extracellular space produced by the fused filopodia processes of the primary mesenchyme cells, the only cells producing a set of necessary matrix proteins. More than ten years ago we showed for the first time that signals from ectoderm cells promoted the expression of one of the major skeleton matrix genes by the primary mesenchyme cells. Since then, many of the crucial steps of this complex activation cascade, from ectoderm cells to embryonic spicules, have been elucidated. The experimental production of skeleton malformations, induced by the exposure to toxic metals or ionizing radiations, served as model to dissect the molecular mechanisms leading to biomineralization. With the aim of understanding the sea urchinskeleton physiology, we analysed the expression of well-known and newly-identified biomineral-related genes, includingthose coding for growth and transcription factors as well as for skeleton matrix proteins. This review summarizes our recent findings on sea urchin embryo skeletogenesis, with a particular attention to the role played by cellular and molecular signaling, approached by the use of experimentally induced skeleton malformations.
Lingua originaleEnglish
pagine (da-a)467-478
Numero di pagine12
RivistaCAHIERS DE BIOLOGIE MARINE
Volume54
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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