Cell-Free Coelomic Fluid Extracts of the Sea Urchin Arbacia lixula Impair Mitochondrial Potential and Cell Cycle Distribution and Stimulate Reactive Oxygen Species Production and Autophagic Activity in Triple-Negative MDA-MB231 Breast Cancer Cells

Claudio Luparello, Vincenzo Arizza, Mirella Vazzana, Federica Affranchi, Valentina Lazzara

Risultato della ricerca: Articlepeer review

3 Citazioni (Scopus)

Abstract

Triple-negative breast cancer (TNBC) is a highly malignant tumor histotype which lackseffective targeted therapies, thereby being considered as the most aggressive form of breastcarcinoma. To identify novel compounds which could counteract TNBC cell growth, we exploredthe in vitro effects of crude extracts and <10 kDa-filtered fractions of the coelomic fluid obtainedfrom the sea urchin Arbacia lixula on TNBC MDA-MB231 cells. We examined cell viability, cycledistribution, apoptotic/autophagic activity, and mitochondrial polarization/cell redox status. Here,we report the first data demonstrating an anti-TNBC effect by A. lixula-derived coelomic fluidextracts. Thus, identification of the water-soluble bioactive component(s) contained in the extractsdeserve(s) further investigation aimed to devise novel promising prevention and/or treatmentagents effective against highly malignant breast tumors.
Lingua originaleEnglish
pagine (da-a)1-13
Numero di pagine13
RivistaJournal of Marine Science and Engineering
Volume8
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Civil and Structural Engineering
  • Water Science and Technology
  • Ocean Engineering

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