Triple-negative breast cancer (TNBC) is a highly malignant tumor histotype which lackseffective targeted therapies, thereby being considered as the most aggressive form of breastcarcinoma. To identify novel compounds which could counteract TNBC cell growth, we exploredthe in vitro effects of crude extracts and <10 kDa-filtered fractions of the coelomic fluid obtainedfrom the sea urchin Arbacia lixula on TNBC MDA-MB231 cells. We examined cell viability, cycledistribution, apoptotic/autophagic activity, and mitochondrial polarization/cell redox status. Here,we report the first data demonstrating an anti-TNBC effect by A. lixula-derived coelomic fluidextracts. Thus, identification of the water-soluble bioactive component(s) contained in the extractsdeserve(s) further investigation aimed to devise novel promising prevention and/or treatmentagents effective against highly malignant breast tumors.
|Numero di pagine||13|
|Rivista||Journal of Marine Science and Engineering|
|Stato di pubblicazione||Published - 2020|
All Science Journal Classification (ASJC) codes