Cell and molecular response to IORT treatment

Minafra, L; Bravatà, V

    Risultato della ricerca: Article

    14 Citazioni (Scopus)

    Abstract

    Ionizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activates both pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated by several genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair and inflammation. This paper describes the latest advances on cellular and molecular response to IR, highlighting the most relevant research data from cell biology, gene expression profiling and epigenetic studies on different tumor cell types. Understanding the cell molecular strategies to choose between death and survival, after an irradiation-induced damage, opens new avenues for the selection of a proper therapy schedule, to counteract cancer growth and preserve healthy surrounding tissue by radiation effects.
    Lingua originaleEnglish
    pagine (da-a)-
    Numero di pagine15
    RivistaTranslational Cancer Research
    Volume3(1)
    Stato di pubblicazionePublished - 2014

    Fingerprint

    Radiotherapy
    Ionizing Radiation
    Radiation Effects
    Gene Expression Profiling
    Epigenomics
    DNA Repair
    Cell Biology
    Signal Transduction
    Neoplasms
    Appointments and Schedules
    Cell Cycle
    Cell Death
    Therapeutics
    Growth
    Research
    Genes

    Cita questo

    Cell and molecular response to IORT treatment. / Minafra, L; Bravatà, V.

    In: Translational Cancer Research, Vol. 3(1), 2014, pag. -.

    Risultato della ricerca: Article

    Minafra, L; Bravatà, V 2014, 'Cell and molecular response to IORT treatment', Translational Cancer Research, vol. 3(1), pagg. -.
    Minafra, L; Bravatà, V. / Cell and molecular response to IORT treatment. In: Translational Cancer Research. 2014 ; Vol. 3(1). pagg. -.
    @article{8db630fceda442afaa1b96ed5598fdbf,
    title = "Cell and molecular response to IORT treatment",
    abstract = "Ionizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activates both pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated by several genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair and inflammation. This paper describes the latest advances on cellular and molecular response to IR, highlighting the most relevant research data from cell biology, gene expression profiling and epigenetic studies on different tumor cell types. Understanding the cell molecular strategies to choose between death and survival, after an irradiation-induced damage, opens new avenues for the selection of a proper therapy schedule, to counteract cancer growth and preserve healthy surrounding tissue by radiation effects.",
    author = "{Minafra, L; Bravat{\`a}, V} and Valentina Bravata'",
    year = "2014",
    language = "English",
    volume = "3(1)",
    pages = "--",
    journal = "Translational Cancer Research",
    issn = "2218-676X",
    publisher = "AME Publishing Company",

    }

    TY - JOUR

    T1 - Cell and molecular response to IORT treatment

    AU - Minafra, L; Bravatà, V

    AU - Bravata', Valentina

    PY - 2014

    Y1 - 2014

    N2 - Ionizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activates both pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated by several genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair and inflammation. This paper describes the latest advances on cellular and molecular response to IR, highlighting the most relevant research data from cell biology, gene expression profiling and epigenetic studies on different tumor cell types. Understanding the cell molecular strategies to choose between death and survival, after an irradiation-induced damage, opens new avenues for the selection of a proper therapy schedule, to counteract cancer growth and preserve healthy surrounding tissue by radiation effects.

    AB - Ionizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activates both pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated by several genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair and inflammation. This paper describes the latest advances on cellular and molecular response to IR, highlighting the most relevant research data from cell biology, gene expression profiling and epigenetic studies on different tumor cell types. Understanding the cell molecular strategies to choose between death and survival, after an irradiation-induced damage, opens new avenues for the selection of a proper therapy schedule, to counteract cancer growth and preserve healthy surrounding tissue by radiation effects.

    UR - http://hdl.handle.net/10447/90890

    M3 - Article

    VL - 3(1)

    SP - -

    JO - Translational Cancer Research

    JF - Translational Cancer Research

    SN - 2218-676X

    ER -