TY - JOUR
T1 - CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma
AU - Cabibi, Daniela
AU - Cappello, Francesco
AU - Rappa, Francesca
AU - Ingrao, Sabrina
AU - Porcasi, Rossana
AU - Rappa, Francesca
AU - Cappello, Francesco
AU - Conway De Macario, Everly
AU - Macario, Alberto J. L.
PY - 2015
Y1 - 2015
N2 - CD1a is involved in presentation to the immune system of lipid antigen derived from tumor cells with subsequent T cell activation. Hsp60 is a molecular chaperone implicated in carcinogenesis by, for instance, modulating the immune reaction against the tumor. We have previously postulated a synergism between CD1a and Hsp60 as a key factor in the activation of an effective antitumor immune response in squamous epithelia. Keratoacantomas (KAs) are benign tumors that however can transform into squamous cell carcinomas (SCCs), but the reasons for this malignization are unknown. In a previous study, we found that CD1a-positive cells are significantly more numerous in KA than in SCC. In this study, we analyzed a series of KAs and SCCs by immunohistochemistry for CD1a and Hsp60. Our results show that the levels of both are significantly lower in KA than in SCC and support the hypothesis that KA may evolve towards SCC if there is a failure of the local modulation of the antitumor immune response. The data also show that immunohistochemistry for CD1a and Hsp60 can be of help in differential diagnosis between KAs and well-differentiated forms of SCC.
AB - CD1a is involved in presentation to the immune system of lipid antigen derived from tumor cells with subsequent T cell activation. Hsp60 is a molecular chaperone implicated in carcinogenesis by, for instance, modulating the immune reaction against the tumor. We have previously postulated a synergism between CD1a and Hsp60 as a key factor in the activation of an effective antitumor immune response in squamous epithelia. Keratoacantomas (KAs) are benign tumors that however can transform into squamous cell carcinomas (SCCs), but the reasons for this malignization are unknown. In a previous study, we found that CD1a-positive cells are significantly more numerous in KA than in SCC. In this study, we analyzed a series of KAs and SCCs by immunohistochemistry for CD1a and Hsp60. Our results show that the levels of both are significantly lower in KA than in SCC and support the hypothesis that KA may evolve towards SCC if there is a failure of the local modulation of the antitumor immune response. The data also show that immunohistochemistry for CD1a and Hsp60 can be of help in differential diagnosis between KAs and well-differentiated forms of SCC.
KW - Biochemistry
KW - CD1a
KW - Cell Biology
KW - Differential diagnosis
KW - Hsp60
KW - Immunohistochemistry
KW - Keratoacantoma
KW - Prognostic evaluation
KW - Squamous cell carcinoma
KW - Treatment
KW - Biochemistry
KW - CD1a
KW - Cell Biology
KW - Differential diagnosis
KW - Hsp60
KW - Immunohistochemistry
KW - Keratoacantoma
KW - Prognostic evaluation
KW - Squamous cell carcinoma
KW - Treatment
UR - http://hdl.handle.net/10447/149110
UR - http://www.springerlink.com/content/120935/
M3 - Article
VL - 21
SP - 131
EP - 137
JO - CELL STRESS & CHAPERONES
JF - CELL STRESS & CHAPERONES
SN - 1355-8145
ER -