CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome.

Francesco Cappello, Giampiero La Rocca, Francesca Rappa, Giovanni Zummo, Rita Anzalone, Salvatore Marasà, Sergi, Rappa, Giampiero La Rocca, Czarnecka, Marasà, Concetta Sergi, Francesca Magno, Salvatore Marasa', Simona Corrao

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Abstract

AIMS:CD1a is a molecule belonging to the highly conserved group of CD1 proteins. Its expression in dendritic cells is related to the presentation of tumour-derived glycolipid antigens to T cells and, consequently, the development of a successful antitumour response. The aim was to investigate the presence of CD1a+ cells in both primary tumours and lymph nodes (LN) of a series of 35 invasive ductal carcinomas by both immunohistochemistry and reverse transcription-polymerase chain reaction.METHODS AND RESULTS:CD1a antigen was more expressed in N0 than N1 breast cancer (P < 0.0001) in both primary lesions and LN metastases and correlated positively and significantly with oestrogen (ER) (P = 0.0025) and progesterone (P = 0.0226) receptor (PR) status, as well as CD4+ and CD8+ T-lymphocyte infiltration.CONCLUSIONS:This is the first report to show a link between CD1a+ mononuclear cells in breast cancer and in paired LN metastases. The positive and significant correlations between the number of CD1a+ cells and positivity of the primary tumour for ER and PR suggest a possible role for CD1a as a prognostic marker for breast cancer, raising the possibility that hormone receptor-positive breast cancer patients may have a better prognosis in the presence of greater dendritic cell infiltration.
Lingua originaleEnglish
pagine (da-a)203-212
Numero di pagine10
RivistaHistopathology
Volume52
Stato di pubblicazionePublished - 2008

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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Cappello, F., La Rocca, G., Rappa, F., Zummo, G., Anzalone, R., Marasà, S., Sergi, Rappa, La Rocca, G., Czarnecka, Marasà, Sergi, C., Magno, F., Marasa', S., & Corrao, S. (2008). CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome. Histopathology, 52, 203-212.