CD146(+) bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis

Claudio Tripodo, Carla Guarnotta, Ada Maria Florena, Giovanni Franco, Sabrina Ingrao, Rossana Porcasi, Umberto Gianelli, Emanuela Boveri, Andrea Di Bernardo, Maria Paola Ternullo

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26 Citazioni (Scopus)

Abstract

AbstractCD146+ bone marrow stromal cells have been recently recognized as clonogenic osteoprogenitors able to organize a complete hematopoietic microenvironment. In this study we used immunohistochemical analysis to investigate the contribution of CD146+ bone marrow osteoprogenitors to the stromal remodeling occurring in the different stages of primary myelofibrosis. We found that CD146+ cells sited at the abluminal side of the bone marrow vessels and branching among hematopoietic cells significantly increased in the advanced stages of primary myelofibrosis (p<0.001), paralleling the extent of fibrosis (r=0.916, p<0.0001) and the microvascular density (r=0.883, p<0.0001). Coherently with a mural cell function, such cells also displayed smooth-muscle actin expression. Our data providing evidence of CD146+ cell involvement in bone marrow stromal changes occurring in primary myelofibrosis are consistent with the capability of these cells to participate in fiber deposition, angiogenesis, and bone formation. They could also represent a rationale for new therapies targeting the bone marrow stroma in primary myelofibrosis. ©2009 Ferrata Storti Foundation.
Lingua originaleEnglish
pagine (da-a)127-130
Numero di pagine4
RivistaHaematologica
Volume94
Stato di pubblicazionePublished - 2009

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All Science Journal Classification (ASJC) codes

  • Hematology

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