CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily

Domenico Lio, Giuseppina Candore, Calogero Caruso, Carmela Rita Balistreri, Giuseppina Colonna Romano, Giuseppe Carruba, Maurizio Calabrò, Ildegarda Campisi, Daniele Di Carlo

Risultato della ricerca: Article

22 Citazioni (Scopus)

Abstract

Prostate cancer (PCa) is the most common malignant neoplasm in older men in Westerncountries. The number of affected older men is increasing. Therefore, strategiesfor prevention of prostate cancer are crucial. To this purpose it is essential to knowthemechanisms involved in development and progression of this malignancy. Recently,an increasing body of genetic and epidemiological studies proposed new hypothesesfor prostate carcinogenesis. It has been suggested that genetic factors as well as exposureto environmental factors such as infectious agents, dietary carcinogens, andhormonal imbalances participate in PCa development. Besides, chronic inflammationplays a key role in PCa. Taking into consideration this complex scenario, in the presentstudy we evaluated whether CCR5 32 deletion of CCR5 gene might be associated withPCa susceptibility. For the control group we used centenarians, since they represent adisease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatoryvariant might be a resistance factor for the development of PCa.
Lingua originaleEnglish
pagine (da-a)289-292
Numero di pagine4
RivistaAnnals of the New York Academy of Sciences
Volume1155
Stato di pubblicazionePublished - 2009

Fingerprint

Sicily
R Factors
Carcinogens
Prostatic Neoplasms
Genes
Alleles
Gene Deletion
Epidemiologic Studies
Prostate
Neoplasms
Carcinogenesis
Prostate Cancer
Allele
Control Groups

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cita questo

@article{22b7716a6b4748898bfc855b6c95cefc,
title = "CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily",
abstract = "Prostate cancer (PCa) is the most common malignant neoplasm in older men in Westerncountries. The number of affected older men is increasing. Therefore, strategiesfor prevention of prostate cancer are crucial. To this purpose it is essential to knowthemechanisms involved in development and progression of this malignancy. Recently,an increasing body of genetic and epidemiological studies proposed new hypothesesfor prostate carcinogenesis. It has been suggested that genetic factors as well as exposureto environmental factors such as infectious agents, dietary carcinogens, andhormonal imbalances participate in PCa development. Besides, chronic inflammationplays a key role in PCa. Taking into consideration this complex scenario, in the presentstudy we evaluated whether CCR5 32 deletion of CCR5 gene might be associated withPCa susceptibility. For the control group we used centenarians, since they represent adisease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatoryvariant might be a resistance factor for the development of PCa.",
author = "Domenico Lio and Giuseppina Candore and Calogero Caruso and Balistreri, {Carmela Rita} and {Colonna Romano}, Giuseppina and Giuseppe Carruba and Maurizio Calabr{\`o} and Ildegarda Campisi and {Di Carlo}, Daniele",
year = "2009",
language = "English",
volume = "1155",
pages = "289--292",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily

AU - Lio, Domenico

AU - Candore, Giuseppina

AU - Caruso, Calogero

AU - Balistreri, Carmela Rita

AU - Colonna Romano, Giuseppina

AU - Carruba, Giuseppe

AU - Calabrò, Maurizio

AU - Campisi, Ildegarda

AU - Di Carlo, Daniele

PY - 2009

Y1 - 2009

N2 - Prostate cancer (PCa) is the most common malignant neoplasm in older men in Westerncountries. The number of affected older men is increasing. Therefore, strategiesfor prevention of prostate cancer are crucial. To this purpose it is essential to knowthemechanisms involved in development and progression of this malignancy. Recently,an increasing body of genetic and epidemiological studies proposed new hypothesesfor prostate carcinogenesis. It has been suggested that genetic factors as well as exposureto environmental factors such as infectious agents, dietary carcinogens, andhormonal imbalances participate in PCa development. Besides, chronic inflammationplays a key role in PCa. Taking into consideration this complex scenario, in the presentstudy we evaluated whether CCR5 32 deletion of CCR5 gene might be associated withPCa susceptibility. For the control group we used centenarians, since they represent adisease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatoryvariant might be a resistance factor for the development of PCa.

AB - Prostate cancer (PCa) is the most common malignant neoplasm in older men in Westerncountries. The number of affected older men is increasing. Therefore, strategiesfor prevention of prostate cancer are crucial. To this purpose it is essential to knowthemechanisms involved in development and progression of this malignancy. Recently,an increasing body of genetic and epidemiological studies proposed new hypothesesfor prostate carcinogenesis. It has been suggested that genetic factors as well as exposureto environmental factors such as infectious agents, dietary carcinogens, andhormonal imbalances participate in PCa development. Besides, chronic inflammationplays a key role in PCa. Taking into consideration this complex scenario, in the presentstudy we evaluated whether CCR5 32 deletion of CCR5 gene might be associated withPCa susceptibility. For the control group we used centenarians, since they represent adisease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatoryvariant might be a resistance factor for the development of PCa.

UR - http://hdl.handle.net/10447/45720

M3 - Article

VL - 1155

SP - 289

EP - 292

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -