Prostate cancer (PCa) is the most common malignant neoplasm in older men in Westerncountries. The number of affected older men is increasing. Therefore, strategiesfor prevention of prostate cancer are crucial. To this purpose it is essential to knowthemechanisms involved in development and progression of this malignancy. Recently,an increasing body of genetic and epidemiological studies proposed new hypothesesfor prostate carcinogenesis. It has been suggested that genetic factors as well as exposureto environmental factors such as infectious agents, dietary carcinogens, andhormonal imbalances participate in PCa development. Besides, chronic inflammationplays a key role in PCa. Taking into consideration this complex scenario, in the presentstudy we evaluated whether CCR5 32 deletion of CCR5 gene might be associated withPCa susceptibility. For the control group we used centenarians, since they represent adisease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatoryvariant might be a resistance factor for the development of PCa.
|Numero di pagine||4|
|Rivista||Annals of the New York Academy of Sciences|
|Stato di pubblicazione||Published - 2009|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Candore, G., Lio, D., Caruso, C., Balistreri, C. R., Colonna Romano, G., Carruba, G., Calabrò, M., Campisi, I., & Di Carlo, D. (2009). CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily. Annals of the New York Academy of Sciences, 1155, 289-292.