CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily

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Abstract

Prostate cancer (PCa) is the most common malignant neoplasm in older men in Western countries. The number of affected older men is increasing. Therefore, strategies for prevention of prostate cancer are crucial. To this purpose it is essential to know themechanisms involved in development and progression of this malignancy. Recently, an increasing body of genetic and epidemiological studies proposed new hypotheses for prostate carcinogenesis. It has been suggested that genetic factors as well as exposure to environmental factors such as infectious agents, dietary carcinogens, and hormonal imbalances participate in PCa development. Besides, chronic inflammation plays a key role in PCa. Taking into consideration this complex scenario, in the present study we evaluated whether CCR5 32 deletion of CCR5 gene might be associated with PCa susceptibility. For the control group we used centenarians, since they represent a disease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatory variant might be a resistance factor for the development of PCa.
Lingua originaleEnglish
pagine (da-a)289-292
Numero di pagine4
RivistaAnnals of the New York Academy of Sciences
Volume1155
Stato di pubblicazionePublished - 2009

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Sicily
R Factors
Carcinogens
Prostatic Neoplasms
Genes
Alleles
Gene Deletion
Epidemiologic Studies
Prostate
Neoplasms
Carcinogenesis
Prostate Cancer
Allele
Control Groups

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • History and Philosophy of Science
  • Biochemistry, Genetics and Molecular Biology(all)

Cita questo

@article{22b7716a6b4748898bfc855b6c95cefc,
title = "CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily",
abstract = "Prostate cancer (PCa) is the most common malignant neoplasm in older men in Western countries. The number of affected older men is increasing. Therefore, strategies for prevention of prostate cancer are crucial. To this purpose it is essential to know themechanisms involved in development and progression of this malignancy. Recently, an increasing body of genetic and epidemiological studies proposed new hypotheses for prostate carcinogenesis. It has been suggested that genetic factors as well as exposure to environmental factors such as infectious agents, dietary carcinogens, and hormonal imbalances participate in PCa development. Besides, chronic inflammation plays a key role in PCa. Taking into consideration this complex scenario, in the present study we evaluated whether CCR5 32 deletion of CCR5 gene might be associated with PCa susceptibility. For the control group we used centenarians, since they represent a disease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatory variant might be a resistance factor for the development of PCa.",
author = "Calogero Caruso and {Colonna Romano}, Giuseppina and Giuseppina Candore and Domenico Lio and {Di Carlo}, Daniele and Balistreri, {Carmela Rita} and Maurizio Calabr{\`o} and Ildegarda Campisi and Giuseppe Carruba",
year = "2009",
language = "English",
volume = "1155",
pages = "289--292",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily

AU - Caruso, Calogero

AU - Colonna Romano, Giuseppina

AU - Candore, Giuseppina

AU - Lio, Domenico

AU - Di Carlo, Daniele

AU - Balistreri, Carmela Rita

AU - Calabrò, Maurizio

AU - Campisi, Ildegarda

AU - Carruba, Giuseppe

PY - 2009

Y1 - 2009

N2 - Prostate cancer (PCa) is the most common malignant neoplasm in older men in Western countries. The number of affected older men is increasing. Therefore, strategies for prevention of prostate cancer are crucial. To this purpose it is essential to know themechanisms involved in development and progression of this malignancy. Recently, an increasing body of genetic and epidemiological studies proposed new hypotheses for prostate carcinogenesis. It has been suggested that genetic factors as well as exposure to environmental factors such as infectious agents, dietary carcinogens, and hormonal imbalances participate in PCa development. Besides, chronic inflammation plays a key role in PCa. Taking into consideration this complex scenario, in the present study we evaluated whether CCR5 32 deletion of CCR5 gene might be associated with PCa susceptibility. For the control group we used centenarians, since they represent a disease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatory variant might be a resistance factor for the development of PCa.

AB - Prostate cancer (PCa) is the most common malignant neoplasm in older men in Western countries. The number of affected older men is increasing. Therefore, strategies for prevention of prostate cancer are crucial. To this purpose it is essential to know themechanisms involved in development and progression of this malignancy. Recently, an increasing body of genetic and epidemiological studies proposed new hypotheses for prostate carcinogenesis. It has been suggested that genetic factors as well as exposure to environmental factors such as infectious agents, dietary carcinogens, and hormonal imbalances participate in PCa development. Besides, chronic inflammation plays a key role in PCa. Taking into consideration this complex scenario, in the present study we evaluated whether CCR5 32 deletion of CCR5 gene might be associated with PCa susceptibility. For the control group we used centenarians, since they represent a disease-free human model. These preliminary results suggest that the CCR5 32 antiinflammatory variant might be a resistance factor for the development of PCa.

UR - http://hdl.handle.net/10447/45720

M3 - Article

VL - 1155

SP - 289

EP - 292

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -