CC chemokine receptor 5 polymorphism in Italian patients with Behcet's disease.

Giovanni Triolo, Piercarlo Sarzi-Puttini, Nicolò Pipitone, Giuseppe Paolazzi, Fabiola Atzeni, Bruno Casali, Renato La Corte, Davide Nicoli, Enrico Farnetti, Davide Filippini, Fabrizio Cantini, Luigi Boiardi, Fabrizio Salvi, Carlo Salvarani, Ignazio Olivieri

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    Abstract

    Objective. To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to and clinical expression of Behçet's disease (BD) in a cohort of Italian patients.Methods. One hundred and ninety-six consecutive Italian patients satisfying the ISG criteria for BD were followed up for 8 years, and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. A standard microlymphocytotoxicity technique was used to serotype HLA-B51. The patients were subgrouped on the basis of the presence or absence of clinical manifestations.Results. The distribution of the CCR5Δ32 genotype differed between BD patients and controls (P = 0.02). The CCR5Δ32 allele was more common in BD patients than in controls [P = 0.02, odds ratio (OR) 2.28 (95% CI 1.1, 4.8)]. Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were significantly more common in BD patients than in controls [P = 0.02, OR 2.37 (95% CI 1.1, 5.1)]. Population-attributable risk was 7.1%. In categorizing patients according to gender, the association between CCR5Δ32 polymorphism and BD was similar in females and males (ORs 2.76 and 2.0, respectively). No significant differences were found when the frequencies of clinical manifestations were compared between CC5RΔ32 allele carriers and non-carriers.Conclusion. CCR5Δ32 polymorphism is associated with an increased susceptibility to develop BD. Chemokines may have a role in the pathophysiology of BD.
    Lingua originaleEnglish
    Numero di pagine0
    RivistaRheumatology
    Volume12
    Stato di pubblicazionePublished - 2012

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    All Science Journal Classification (ASJC) codes

    • Rheumatology
    • Pharmacology (medical)

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    Triolo, G., Sarzi-Puttini, P., Pipitone, N., Paolazzi, G., Atzeni, F., Casali, B., La Corte, R., Nicoli, D., Farnetti, E., Filippini, D., Cantini, F., Boiardi, L., Salvi, F., Salvarani, C., & Olivieri, I. (2012). CC chemokine receptor 5 polymorphism in Italian patients with Behcet's disease. Rheumatology, 12.