3 Citazioni (Scopus)

Abstract

Abstract Cathepsin L is a ubiquitous lysosomal cysteineendopeptidase that is mainly involved in the metabolicturnover of intracellular proteins. However, it is now wellestablished that this enzyme may also be implicated in theregulation of other important biological processes includ-ing bone resorption. Therefore, altered expression levels ofCathepsin L may result in disturbances of bone homeo-stasis and, eventually, in the onset of pathological condi-tions associated with altered bone turnover. Theseobservations support the concept that Cathepsin L may beregarded as an additional target for the development ofnovel therapeutic options for the treatment of patients withbone diseases. This review provides insight into the mostrecent advances in understanding the role of Cathepsin L innormal and pathological bone remodeling and discusses thepotential clinical and therapeutic applications related tothese findings.
Lingua originaleEnglish
pagine (da-a)107-121
Numero di pagine15
RivistaDefault journal
Volume9
Stato di pubblicazionePublished - 2011

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Cathepsin L
Bone Remodeling
Bone and Bones
Biological Phenomena
Bone Resorption
Therapeutics
Enzymes
Proteins

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cita questo

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title = "Cathepsin L in normal and pathological bone reodeling",
abstract = "Abstract Cathepsin L is a ubiquitous lysosomal cysteineendopeptidase that is mainly involved in the metabolicturnover of intracellular proteins. However, it is now wellestablished that this enzyme may also be implicated in theregulation of other important biological processes includ-ing bone resorption. Therefore, altered expression levels ofCathepsin L may result in disturbances of bone homeo-stasis and, eventually, in the onset of pathological condi-tions associated with altered bone turnover. Theseobservations support the concept that Cathepsin L may beregarded as an additional target for the development ofnovel therapeutic options for the treatment of patients withbone diseases. This review provides insight into the mostrecent advances in understanding the role of Cathepsin L innormal and pathological bone remodeling and discusses thepotential clinical and therapeutic applications related tothese findings.",
keywords = "Bone diseases, Bone metastasis, Cancer, Cathepsin L, Cysteine proteinases, Proteinase inhibitors",
author = "Carla Flandina and Gaetano Leto and Tumminello, {Francesca Maria} and Marilena Crescimanno and Sepporta, {Maria Vittoria}",
year = "2011",
language = "English",
volume = "9",
pages = "107--121",
journal = "Default journal",

}

TY - JOUR

T1 - Cathepsin L in normal and pathological bone reodeling

AU - Flandina, Carla

AU - Leto, Gaetano

AU - Tumminello, Francesca Maria

AU - Crescimanno, Marilena

AU - Sepporta, Maria Vittoria

PY - 2011

Y1 - 2011

N2 - Abstract Cathepsin L is a ubiquitous lysosomal cysteineendopeptidase that is mainly involved in the metabolicturnover of intracellular proteins. However, it is now wellestablished that this enzyme may also be implicated in theregulation of other important biological processes includ-ing bone resorption. Therefore, altered expression levels ofCathepsin L may result in disturbances of bone homeo-stasis and, eventually, in the onset of pathological condi-tions associated with altered bone turnover. Theseobservations support the concept that Cathepsin L may beregarded as an additional target for the development ofnovel therapeutic options for the treatment of patients withbone diseases. This review provides insight into the mostrecent advances in understanding the role of Cathepsin L innormal and pathological bone remodeling and discusses thepotential clinical and therapeutic applications related tothese findings.

AB - Abstract Cathepsin L is a ubiquitous lysosomal cysteineendopeptidase that is mainly involved in the metabolicturnover of intracellular proteins. However, it is now wellestablished that this enzyme may also be implicated in theregulation of other important biological processes includ-ing bone resorption. Therefore, altered expression levels ofCathepsin L may result in disturbances of bone homeo-stasis and, eventually, in the onset of pathological condi-tions associated with altered bone turnover. Theseobservations support the concept that Cathepsin L may beregarded as an additional target for the development ofnovel therapeutic options for the treatment of patients withbone diseases. This review provides insight into the mostrecent advances in understanding the role of Cathepsin L innormal and pathological bone remodeling and discusses thepotential clinical and therapeutic applications related tothese findings.

KW - Bone diseases

KW - Bone metastasis

KW - Cancer

KW - Cathepsin L

KW - Cysteine proteinases

KW - Proteinase inhibitors

UR - http://hdl.handle.net/10447/55377

M3 - Article

VL - 9

SP - 107

EP - 121

JO - Default journal

JF - Default journal

ER -