Abstract

Abstract Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes includ- ing bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeo- stasis and, eventually, in the onset of pathological condi- tions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone diseases. This review provides insight into the most recent advances in understanding the role of Cathepsin L in normal and pathological bone remodeling and discusses the potential clinical and therapeutic applications related to these findings.
Lingua originaleEnglish
pagine (da-a)107-121
Numero di pagine15
RivistaClinical Reviews in Bone and Mineral Metabolism
Volume9
Stato di pubblicazionePublished - 2011

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Cathepsin L
Bone Remodeling
Bone and Bones
Biological Phenomena
Bone Resorption
Therapeutics
Enzymes
Proteins

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Orthopedics and Sports Medicine

Cita questo

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title = "Cathepsin L in normal and pathological bone reodeling",
abstract = "Abstract Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes includ- ing bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeo- stasis and, eventually, in the onset of pathological condi- tions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone diseases. This review provides insight into the most recent advances in understanding the role of Cathepsin L in normal and pathological bone remodeling and discusses the potential clinical and therapeutic applications related to these findings.",
keywords = "Bone diseases, Bone metastasis, Cancer, Cathepsin L, Cysteine proteinases, Proteinase inhibitors",
author = "Tumminello, {Francesca Maria} and Marilena Crescimanno and Carla Flandina and Gaetano Leto and Sepporta, {Maria Vittoria}",
year = "2011",
language = "English",
volume = "9",
pages = "107--121",
journal = "Clinical Reviews in Bone and Mineral Metabolism",
issn = "1534-8644",
publisher = "Humana Press",

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TY - JOUR

T1 - Cathepsin L in normal and pathological bone reodeling

AU - Tumminello, Francesca Maria

AU - Crescimanno, Marilena

AU - Flandina, Carla

AU - Leto, Gaetano

AU - Sepporta, Maria Vittoria

PY - 2011

Y1 - 2011

N2 - Abstract Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes includ- ing bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeo- stasis and, eventually, in the onset of pathological condi- tions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone diseases. This review provides insight into the most recent advances in understanding the role of Cathepsin L in normal and pathological bone remodeling and discusses the potential clinical and therapeutic applications related to these findings.

AB - Abstract Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes includ- ing bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeo- stasis and, eventually, in the onset of pathological condi- tions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone diseases. This review provides insight into the most recent advances in understanding the role of Cathepsin L in normal and pathological bone remodeling and discusses the potential clinical and therapeutic applications related to these findings.

KW - Bone diseases, Bone metastasis, Cancer, Cathepsin L, Cysteine proteinases, Proteinase inhibitors

UR - http://hdl.handle.net/10447/55377

M3 - Article

VL - 9

SP - 107

EP - 121

JO - Clinical Reviews in Bone and Mineral Metabolism

JF - Clinical Reviews in Bone and Mineral Metabolism

SN - 1534-8644

ER -