TY - JOUR
T1 - Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies
AU - Veronese, Nicola
AU - Forzan, Monica
AU - Veronese, Nicola
AU - Pinato, Claudia
AU - Carvalho, Andrè F.
AU - Collantoni, Enrico
AU - Piva, Ivana
AU - Meneguzzo, Paolo
AU - Favaro, Angela
AU - Siani, Roberta
AU - Stubbs, Brendon
AU - Fontana, Francesca
AU - Cassina, Matteo
AU - Gallicchio, Davide
AU - Solmi, Marco
AU - Siani, Roberta
AU - Salvo, Pierandrea
AU - Correll, Christoph U.
AU - Santonastaso, Paolo
AU - Clementi, Maurizio
AU - Tenconi, Elena
PY - 2017
Y1 - 2017
N2 - Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96–1.04, p-values: 0.46–0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94–1.04, p-values: 0.31–0.61, I2 = 0%) or BN (ORs: 0.80–1.09, p-values: 0.28–0.64, I2 = 0–44%). Conclusions: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
AB - Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96–1.04, p-values: 0.46–0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94–1.04, p-values: 0.31–0.61, I2 = 0%) or BN (ORs: 0.80–1.09, p-values: 0.28–0.64, I2 = 0–44%). Conclusions: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
UR - http://hdl.handle.net/10447/464634
M3 - Article
SN - 1072-4133
VL - 25
SP - 524
EP - 532
JO - European Eating Disorders Review
JF - European Eating Disorders Review
ER -