Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies

Nicola Veronese, Monica Forzan, Nicola Veronese, Claudia Pinato, Andrè F. Carvalho, Enrico Collantoni, Ivana Piva, Paolo Meneguzzo, Angela Favaro, Roberta Siani, Brendon Stubbs, Francesca Fontana, Matteo Cassina, Davide Gallicchio, Marco Solmi, Pierandrea Salvo, Christoph U. Correll, Paolo Santonastaso, Maurizio Clementi, Elena Tenconi

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)


Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96–1.04, p-values: 0.46–0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94–1.04, p-values: 0.31–0.61, I2 = 0%) or BN (ORs: 0.80–1.09, p-values: 0.28–0.64, I2 = 0–44%). Conclusions: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Lingua originaleEnglish
pagine (da-a)524-532
Numero di pagine9
RivistaEuropean Eating Disorders Review
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Clinical Psychology

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