TY - JOUR
T1 - Catalysis Concepts in Medicinal Inorganic Chemistry
AU - Terenzi, Alessio
AU - Terenzi, Alessio
AU - Alonso-De Castro, Silvia
AU - Gurruchaga-Pereda, Juan
AU - Salassa, Luca
PY - 2019
Y1 - 2019
N2 - Catalysis has strongly emerged in the field of medicinal inorganic chemistry as a suitable tool to deliver new drug candidates and to overcome drawbacks associated to metallodrugs. In this Concept article, we discuss representative examples of how catalysis has been applied in combination with metal complexes to deliver new therapy approaches. In particular, we explain key achievements in the design of catalytic metallodrugs that damage biomolecular targets and in the development of metal catalysis schemes for the activation of exogenous organic prodrugs. Moreover, we discuss our recent discoveries on the flavin-mediated bioorthogonal catalytic activation of metal-based prodrugs; a new catalysis strategy in which metal complexes are unconventionally employed as substrates rather than catalysts.
AB - Catalysis has strongly emerged in the field of medicinal inorganic chemistry as a suitable tool to deliver new drug candidates and to overcome drawbacks associated to metallodrugs. In this Concept article, we discuss representative examples of how catalysis has been applied in combination with metal complexes to deliver new therapy approaches. In particular, we explain key achievements in the design of catalytic metallodrugs that damage biomolecular targets and in the development of metal catalysis schemes for the activation of exogenous organic prodrugs. Moreover, we discuss our recent discoveries on the flavin-mediated bioorthogonal catalytic activation of metal-based prodrugs; a new catalysis strategy in which metal complexes are unconventionally employed as substrates rather than catalysts.
KW - Pharmaceutical
KW - antiproliferation; bioinorganic chemistry; metallodrugs; photochemistry; prodrugs; Antineoplastic Agents; Catalysis; Coordination Complexes; Humans; Inorganic Chemicals; Prodrugs; Chemistry
KW - Pharmaceutical
KW - antiproliferation; bioinorganic chemistry; metallodrugs; photochemistry; prodrugs; Antineoplastic Agents; Catalysis; Coordination Complexes; Humans; Inorganic Chemicals; Prodrugs; Chemistry
UR - http://hdl.handle.net/10447/392779
UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3765
M3 - Article
VL - 25
SP - 6651
EP - 6660
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
SN - 0947-6539
ER -