TY - JOUR
T1 - Carotid intima media thickness and coronary atherosclerosis linkage in symptomatic intermediate risk patients evaluated by coronary computed tomography angiography.
AU - Midiri, Massimo
AU - Guaricci, Andrea Igoren
AU - Maffei, Erica
AU - Martini, Chiara
AU - Montrone, Deodata
AU - Arcadi, Teresa
AU - De Rosa, Fiorella
AU - Cocco, Domenico
AU - De Luca, Maria
AU - Di Biase, Matteo
AU - Macarini, Luca
AU - Cademartiri, Filippo
AU - Pontone, Gianluca
AU - Brunetti, Natale Daniele
PY - 2014
Y1 - 2014
N2 - BackgroundThere is a growing evidence that carotid intima media thickness (CIMT) is associated with coronary artery disease (CAD) and it should be used as a predictor of atherosclerotic burden of coronary arteries. However, these studies have been performed by using invasive coronary angiography (ICA) and in high-risk patients for CAD. The purpose of this study was to evaluate the correlation between CIMT by ultrasound and coronary atherosclerosis in symptomatic intermediate risk patients by coronary computed tomography angiography (CCTA).MethodsWe enrolled 204 consecutive symptomatic patients (mean age: 61 ± 10; men: 118) and intermediate risk for CAD. All patients underwent CIMT ultrasound evaluation and CCTA. Coronary artery calcium score (CACS), characteristics of plaques, severity of CAD, segment involvement score (SIS) and Gensini's score were assessed and compared with CIMT values.ResultsCIMT has been proved as an independent predictor of a number of coronary artery plaques, overall number of mixed and remodeled plaques, presence of obstructive CAD, high SIS and Gensini's score (HR 1.2, CI 1.05–1.42, p 0.01; HR 1.2, CI 1.01–1.41, p 0.03; HR 9.0, CI 1.37–59.7, p 0.02; HR 21.0, CI 2.40–184, p < 0.01; HR 1.2, CI 1.08–1.42, p < 0.01; HR 1.2, CI 1.08–1.42, p < 0.01, respectively). A cut-off value > 1.3 was associated with a better positive and negative predictive value (100% and 69%) to predict the combined endpoint of presence and mixed and/or remodeled coronary artery plaques.ConclusionsCIMT is an independent predictor of coronary atherosclerotic burden as detected by CCTA in symptomatic intermediate risk patients.
AB - BackgroundThere is a growing evidence that carotid intima media thickness (CIMT) is associated with coronary artery disease (CAD) and it should be used as a predictor of atherosclerotic burden of coronary arteries. However, these studies have been performed by using invasive coronary angiography (ICA) and in high-risk patients for CAD. The purpose of this study was to evaluate the correlation between CIMT by ultrasound and coronary atherosclerosis in symptomatic intermediate risk patients by coronary computed tomography angiography (CCTA).MethodsWe enrolled 204 consecutive symptomatic patients (mean age: 61 ± 10; men: 118) and intermediate risk for CAD. All patients underwent CIMT ultrasound evaluation and CCTA. Coronary artery calcium score (CACS), characteristics of plaques, severity of CAD, segment involvement score (SIS) and Gensini's score were assessed and compared with CIMT values.ResultsCIMT has been proved as an independent predictor of a number of coronary artery plaques, overall number of mixed and remodeled plaques, presence of obstructive CAD, high SIS and Gensini's score (HR 1.2, CI 1.05–1.42, p 0.01; HR 1.2, CI 1.01–1.41, p 0.03; HR 9.0, CI 1.37–59.7, p 0.02; HR 21.0, CI 2.40–184, p < 0.01; HR 1.2, CI 1.08–1.42, p < 0.01; HR 1.2, CI 1.08–1.42, p < 0.01, respectively). A cut-off value > 1.3 was associated with a better positive and negative predictive value (100% and 69%) to predict the combined endpoint of presence and mixed and/or remodeled coronary artery plaques.ConclusionsCIMT is an independent predictor of coronary atherosclerotic burden as detected by CCTA in symptomatic intermediate risk patients.
UR - http://hdl.handle.net/10447/103287
M3 - Article
VL - 176
SP - 988
EP - 993
JO - INTERNATIONAL JOURNAL OF CARDIOLOGY
JF - INTERNATIONAL JOURNAL OF CARDIOLOGY
SN - 0167-5273
ER -