Cardiovascular Events in Moderately to Severely Obese Obstructive Sleep Apnea Patients on Positive Airway Pressure Therapy

Maria Rosaria Bonsignore, Jean-Christian Borel, Jean Louis Pépin, Louis M. Galerneau, Renaud Tamisier, Anna Maria Marotta

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)


Background: In moderately to severely obese patients withobstructive sleep apnea (OSA), the effects of long-term positiveairway pressure (PAP) treatment on cardiovascular riskare poorly defined. Purpose: To assess the effect of continuouspositive airway pressure (CPAP) or noninvasive ventilation(NIV) on the occurrence of cardiovascular events inobese OSA patients. Methods: We performed a noninterventionalobservational study in obese OSA patients recruitedbetween 2007 and 2010 at the Sleep Center, University ofGrenoble, treated with CPAP or NIV, and followed for 5.6years by a single home care provider. Baseline clinical characteristics,blood chemistry, and respiratory and vascularfunction were assessed. Incident cardiovascular events wereinvestigated by phone interviews. Results: A total of 103 patients(55 men, 48 women; age and body mass index [BMI] atdiagnosis 54.1 ± 10.5 years and 40.3 ± 5.5, respectively [mean± standard deviation]; CPAP: n = 75; NIV: n = 28) agreed toparticipate in the study. Grade I, II, and III obesity occurred in 17.5, 33.0, and 49.5% of the sample, respectively. In patientsusing PAP treatment ( n = 69), the mean nightly use was6.3 ± 2.4 h. Thirty-one patients stopped PAP treatment duringfollow-up. Three patients on NIV died. Nonfatal cardiovascularevents ( n = 27) occurred in 19 patients, who wereolder and showed higher number of comorbidities and triglyceridelevels than patients without events. In the patientswho interrupted treatment, the event rate was high and increasedwith the number of comorbidities, while BMI atbaseline did not predict events. Conclusions: The study suggeststhat regular PAP treatment may be associated withprotection against cardiovascular risk in obese OSA patients,especially in the presence of multiple comorbidities.
Lingua originaleEnglish
pagine (da-a)179-188
Numero di pagine10
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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