TY - JOUR
T1 - Cardiac complications in thalassemia: noninvasive detection methods and new directions in the clinical management.
AU - Midiri, Massimo
AU - Bartolotta, Tommaso Vincenzo
AU - Renda, Disma
AU - Bartolotta, Tommaso Vincenzo
AU - Mancuso, Luigi
AU - Midiri, Massimo
AU - Maggio, Aurelio
AU - Panzarella, Gaetano
PY - 2003
Y1 - 2003
N2 - The natural history of thalassemia has shown substantial change during these years. This applies for each aspect of the pathology (for example, endocrinological, hepatological and psychological) and also for the pathology that has presented and still presents the main cause of death: myocardial dysfunction. In this review, the pathophysiology of cardiac complications, possible role of myocarditis, new knowledge on pathogenesis, and noninvasive detection methods for iron overload in the heart are pointed out. Prophylaxis of cardiomyopathy and new therapy strategies of myocardial dysfunction, including the impact of the new chelation treatment, are discussed.
AB - The natural history of thalassemia has shown substantial change during these years. This applies for each aspect of the pathology (for example, endocrinological, hepatological and psychological) and also for the pathology that has presented and still presents the main cause of death: myocardial dysfunction. In this review, the pathophysiology of cardiac complications, possible role of myocarditis, new knowledge on pathogenesis, and noninvasive detection methods for iron overload in the heart are pointed out. Prophylaxis of cardiomyopathy and new therapy strategies of myocardial dysfunction, including the impact of the new chelation treatment, are discussed.
KW - Cardiac complications in thalassemia
KW - Cardiac complications in thalassemia
UR - http://hdl.handle.net/10447/46977
M3 - Article
VL - 2003-09
JO - Expert Review of Cardiovascular Therapy
JF - Expert Review of Cardiovascular Therapy
SN - 1477-9072
ER -