Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: A case report

Cabibi D; Martorana A; Cappello F; Barresi E; Di Gangi C; Rodolico V

Risultato della ricerca: Article

18 Citazioni (Scopus)

Abstract

Background: Transformation of a cystic benign teratoma of the ovary into a "carcinosarcoma" has very rarely been reported and its histogenetic origin is still debated. Case presentation: A case of carcinosarcoma arising from a dermoid cyst is reported. The tumor showed cystic areas delimited by normal squamous epithelium, with transitional areas through dysplastic epithelium to "in situ" and infiltrating squamous cell carcinoma (SCC). The sarcomatous component showed compact tissue composed of round cells concentrically arranged around small vessels, spindle, and pleomorphic cells with a high nuclear-cytoplasmic ratio. Positive staining for vimentin, alpha smooth muscle actin and CD10, as well as P53 and P63, was found in the sarcomatous component and in some atypical basal cells of the squamous epithelium, which also showed the usual epithelial markers. Conclusion: To the best of our knowledge, this is the first case of carcinosarcoma arising from a dermoid cyst in which a histogenetic origin from totipotent stem cells, located in the basal squamous layer, is supported by immunohistochemical findings. © 2006 Cabibi et al; licensee BioMed Central Ltd.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine4
RivistaBMC Cancer
Volume6
Stato di pubblicazionePublished - 2006

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Carcinosarcoma
Dermoid Cyst
Ovary
Epithelium
Teratoma
Totipotent Stem Cells
Vimentin
Smooth Muscle
Actins
Squamous Cell Carcinoma
Staining and Labeling
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research
  • Genetics

Cita questo

Cabibi D; Martorana A; Cappello F; Barresi E; Di Gangi C; Rodolico V (2006). Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: A case report. BMC Cancer, 6, -.

Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: A case report. / Cabibi D; Martorana A; Cappello F; Barresi E; Di Gangi C; Rodolico V.

In: BMC Cancer, Vol. 6, 2006, pag. -.

Risultato della ricerca: Article

Cabibi D; Martorana A; Cappello F; Barresi E; Di Gangi C; Rodolico V 2006, 'Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: A case report', BMC Cancer, vol. 6, pagg. -.
Cabibi D; Martorana A; Cappello F; Barresi E; Di Gangi C; Rodolico V. Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: A case report. BMC Cancer. 2006;6:-.
Cabibi D; Martorana A; Cappello F; Barresi E; Di Gangi C; Rodolico V. / Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: A case report. In: BMC Cancer. 2006 ; Vol. 6. pagg. -.
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abstract = "Background: Transformation of a cystic benign teratoma of the ovary into a {"}carcinosarcoma{"} has very rarely been reported and its histogenetic origin is still debated. Case presentation: A case of carcinosarcoma arising from a dermoid cyst is reported. The tumor showed cystic areas delimited by normal squamous epithelium, with transitional areas through dysplastic epithelium to {"}in situ{"} and infiltrating squamous cell carcinoma (SCC). The sarcomatous component showed compact tissue composed of round cells concentrically arranged around small vessels, spindle, and pleomorphic cells with a high nuclear-cytoplasmic ratio. Positive staining for vimentin, alpha smooth muscle actin and CD10, as well as P53 and P63, was found in the sarcomatous component and in some atypical basal cells of the squamous epithelium, which also showed the usual epithelial markers. Conclusion: To the best of our knowledge, this is the first case of carcinosarcoma arising from a dermoid cyst in which a histogenetic origin from totipotent stem cells, located in the basal squamous layer, is supported by immunohistochemical findings. {\circledC} 2006 Cabibi et al; licensee BioMed Central Ltd.",
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T1 - Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: A case report

AU - Cabibi D; Martorana A; Cappello F; Barresi E; Di Gangi C; Rodolico V

AU - Barresi, Elisabetta

AU - Rodolico, Vito

AU - Cappello, Francesco

AU - Cabibi, Daniela

AU - Martorana, Anna

PY - 2006

Y1 - 2006

N2 - Background: Transformation of a cystic benign teratoma of the ovary into a "carcinosarcoma" has very rarely been reported and its histogenetic origin is still debated. Case presentation: A case of carcinosarcoma arising from a dermoid cyst is reported. The tumor showed cystic areas delimited by normal squamous epithelium, with transitional areas through dysplastic epithelium to "in situ" and infiltrating squamous cell carcinoma (SCC). The sarcomatous component showed compact tissue composed of round cells concentrically arranged around small vessels, spindle, and pleomorphic cells with a high nuclear-cytoplasmic ratio. Positive staining for vimentin, alpha smooth muscle actin and CD10, as well as P53 and P63, was found in the sarcomatous component and in some atypical basal cells of the squamous epithelium, which also showed the usual epithelial markers. Conclusion: To the best of our knowledge, this is the first case of carcinosarcoma arising from a dermoid cyst in which a histogenetic origin from totipotent stem cells, located in the basal squamous layer, is supported by immunohistochemical findings. © 2006 Cabibi et al; licensee BioMed Central Ltd.

AB - Background: Transformation of a cystic benign teratoma of the ovary into a "carcinosarcoma" has very rarely been reported and its histogenetic origin is still debated. Case presentation: A case of carcinosarcoma arising from a dermoid cyst is reported. The tumor showed cystic areas delimited by normal squamous epithelium, with transitional areas through dysplastic epithelium to "in situ" and infiltrating squamous cell carcinoma (SCC). The sarcomatous component showed compact tissue composed of round cells concentrically arranged around small vessels, spindle, and pleomorphic cells with a high nuclear-cytoplasmic ratio. Positive staining for vimentin, alpha smooth muscle actin and CD10, as well as P53 and P63, was found in the sarcomatous component and in some atypical basal cells of the squamous epithelium, which also showed the usual epithelial markers. Conclusion: To the best of our knowledge, this is the first case of carcinosarcoma arising from a dermoid cyst in which a histogenetic origin from totipotent stem cells, located in the basal squamous layer, is supported by immunohistochemical findings. © 2006 Cabibi et al; licensee BioMed Central Ltd.

UR - http://hdl.handle.net/10447/24923

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JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

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