Carbon-Phosphorus Coupling from C^N Cyclometalated Au(III) Complexes

Giampaolo Barone, Riccardo Bonsignore, Wim T. Klooster, Sophie R. Thomas, Didier Bourissou, Wim T. Klooster, Simon J. Coles, Angela Casini, Robert L. Jenkins, Robert L. Jenkins

Risultato della ricerca: Articlepeer review

9 Citazioni (Scopus)

Abstract

With the aim of exploiting new organometallic species for cross-coupling reactions, we report here on the Au(III)-mediated Caryl-P bond formation occurring upon reaction of C^N cyclometalated Au(III) complexes with phosphines. The [Au(C^N)Cl2] complex 1 featuring the bidentate 2-benzoylpyridine (CCON) scaffold was found to react with PTA (1,3,5-triaza-7-phosphaadamantane) under mild conditions, including in water, to afford the corresponding phosphonium 5 via C-P reductive elimination. A mechanism is proposed for the title reaction based on in situ 31P1H NMR and HR-ESI-MS analyses combined with DFT calculations. The C-P coupling has been generalized to other C^N cyclometalated Au(III) complexes and other tertiary phosphines. Overall, this work provides new insights into the reactivity of cyclometalated Au(III) compounds and establishes initial structure-activity relationships to develop Au(III)-mediated C-P cross-coupling reactions.
Lingua originaleEnglish
pagine (da-a)4226-4231
Numero di pagine6
RivistaCHEMISTRY-A EUROPEAN JOURNAL
Volume26
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1600.1605???

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