Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs

Giorgio Stassi, Fritz H. Bach, Magdi H. Yacoub, Felicetta Simeone, Antonio Mancini, Giuseppe D'Alise, Alberto Froio, Roberto Giovannoni, Ernesto Di Florio, Antonino Musumeci, Ewa Slominska, Marialuisa Lavitrano, Fulvio Calise, Leo E. Otterbein, Massimo Maccherini, Adele Bracco, Monica Forni, Emanuele Cozzi, Maria Laura Bacci, Ryszard T. SmolenskiAntonella Mancini, Mariella Patti

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89 Citazioni (Scopus)

Abstract

Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.
Lingua originaleEnglish
pagine (da-a)1093-1095
Numero di pagine3
RivistaTHE FASEB JOURNAL
Volume2004
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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    Stassi, G., Bach, F. H., Yacoub, M. H., Simeone, F., Mancini, A., D'Alise, G., Froio, A., Giovannoni, R., Di Florio, E., Musumeci, A., Slominska, E., Lavitrano, M., Calise, F., Otterbein, L. E., Maccherini, M., Bracco, A., Forni, M., Cozzi, E., Laura Bacci, M., ... Patti, M. (2004). Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. THE FASEB JOURNAL, 2004, 1093-1095.