Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs

Giorgio Stassi, Fritz H. Bach, Magdi H. Yacoub, Felicetta Simeone, Antonio Mancini, Giuseppe D'Alise, Alberto Froio, Roberto Giovannoni, Ernesto Di Florio, Antonino Musumeci, Ewa Slominska, Marialuisa Lavitrano, Fulvio Calise, Leo E. Otterbein, Massimo Maccherini, Adele Bracco, Monica Forni, Emanuele Cozzi, Maria Laura Bacci, Ryszard T. SmolenskiAntonella Mancini, Mariella Patti

Risultato della ricerca: Article

86 Citazioni (Scopus)

Abstract

Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.
Lingua originaleEnglish
pagine (da-a)1093-1095
Numero di pagine3
RivistaDefault journal
Volume2004
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cita questo

Stassi, G., Bach, F. H., Yacoub, M. H., Simeone, F., Mancini, A., D'Alise, G., ... Patti, M. (2004). Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. Default journal, 2004, 1093-1095.

Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. / Stassi, Giorgio; Bach, Fritz H.; Yacoub, Magdi H.; Simeone, Felicetta; Mancini, Antonio; D'Alise, Giuseppe; Froio, Alberto; Giovannoni, Roberto; Di Florio, Ernesto; Musumeci, Antonino; Slominska, Ewa; Lavitrano, Marialuisa; Calise, Fulvio; Otterbein, Leo E.; Maccherini, Massimo; Bracco, Adele; Forni, Monica; Cozzi, Emanuele; Laura Bacci, Maria; Smolenski, Ryszard T.; Mancini, Antonella; Patti, Mariella.

In: Default journal, Vol. 2004, 2004, pag. 1093-1095.

Risultato della ricerca: Article

Stassi, G, Bach, FH, Yacoub, MH, Simeone, F, Mancini, A, D'Alise, G, Froio, A, Giovannoni, R, Di Florio, E, Musumeci, A, Slominska, E, Lavitrano, M, Calise, F, Otterbein, LE, Maccherini, M, Bracco, A, Forni, M, Cozzi, E, Laura Bacci, M, Smolenski, RT, Mancini, A & Patti, M 2004, 'Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs', Default journal, vol. 2004, pagg. 1093-1095.
Stassi, Giorgio ; Bach, Fritz H. ; Yacoub, Magdi H. ; Simeone, Felicetta ; Mancini, Antonio ; D'Alise, Giuseppe ; Froio, Alberto ; Giovannoni, Roberto ; Di Florio, Ernesto ; Musumeci, Antonino ; Slominska, Ewa ; Lavitrano, Marialuisa ; Calise, Fulvio ; Otterbein, Leo E. ; Maccherini, Massimo ; Bracco, Adele ; Forni, Monica ; Cozzi, Emanuele ; Laura Bacci, Maria ; Smolenski, Ryszard T. ; Mancini, Antonella ; Patti, Mariella. / Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. In: Default journal. 2004 ; Vol. 2004. pagg. 1093-1095.
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abstract = "Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.",
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T1 - Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs

AU - Stassi, Giorgio

AU - Bach, Fritz H.

AU - Yacoub, Magdi H.

AU - Simeone, Felicetta

AU - Mancini, Antonio

AU - D'Alise, Giuseppe

AU - Froio, Alberto

AU - Giovannoni, Roberto

AU - Di Florio, Ernesto

AU - Musumeci, Antonino

AU - Slominska, Ewa

AU - Lavitrano, Marialuisa

AU - Calise, Fulvio

AU - Otterbein, Leo E.

AU - Maccherini, Massimo

AU - Bracco, Adele

AU - Forni, Monica

AU - Cozzi, Emanuele

AU - Laura Bacci, Maria

AU - Smolenski, Ryszard T.

AU - Mancini, Antonella

AU - Patti, Mariella

PY - 2004

Y1 - 2004

N2 - Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.

AB - Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.

KW - apoptosis

KW - heart arrest

KW - hypoxia

KW - ischemia reperfusion

UR - http://hdl.handle.net/10447/31676

M3 - Article

VL - 2004

SP - 1093

EP - 1095

JO - Default journal

JF - Default journal

ER -