Canhistographicanalysisofapparentdiffusioncoefficienthelpdiscriminatebetweenbenignandmalignantnodesinheadandnecksquamouscellcarcinoma?

    Risultato della ricerca: Otherpeer review

    Abstract

    Objective:Toinvestigatehistographicanalysisofapparentdiffusioncoefficient(ADC)measurementsasdiscriminatorsofbenignfrommalignantlymphnodesinpatientswithheadandneck(H&N)squamouscellcarcinoma(SCC)MaterialsandMethods:SeventeenpatientswithH&NSCCstagedfornodaldiseaseusinganatomicalMRI,contrastenhancedCTandultrasound±fineneedleaspirationgaveinformedconsentforadditionalMRdiffusionweightedimaging(DWI).AxialDWIwasperformedbyshorttauinversionrecovery(STIR)echoplanarimagingandtraceweightedimagesobtainedb0,50,100,300,600and1000.ImageanalysiswasconductedusingJim5.0.NodaldiseaseandcontralateralbenignnodaltissuewascontouredandallpixelADCvalueswithinthevolumetricregionsrecorded.MalignantandbenignnodalADChistographicfeatures(kurtosisandskewness)werecomparedusingastudentttest.Recieveroperatingcharacteristic(ROC)analysiswasusedtocomparetheutilityofhistographicmeasuresforpredictionofmalignantnodes.Results:MedianADCformalignantandbenignnodeswas0.928(range0.46to1.1)and0.948(range0.77to1.3)x10-‐3mm2-‐1respectively,withnosignificantdifferencebetweenthetwogroups(p=0.181).Medianskewnessofmalignant(1.07,range-‐0.29to2.84)histogramswassignificantlyhigherthanforbenign(0.23,range-‐1.329to1.14)histograms(p=0.006).Therewasnosignificantdifferenceinkurtosisbetweenthetwogroups(p=0.22).Histographicskewnesswasagoodpredictorofabnormalnodes(areaundertheROCcurve=0.798).Conclusions:HistographicanalysisofADCcanhelpdifferentiatemalignantfrombenignnodesforpatientswithSCCoftheheadandneck.
    Lingua originaleEnglish
    Numero di pagine1
    Stato di pubblicazionePublished - 2011

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