Cancer invasion ad metastasis: discovering new targets for diagnosis and therapeutics

Risultato della ricerca: Article

Abstract

Cancer invasion and metastases are the hallmarks of malignant tumors and the cause of most cancer deaths. Molecular alterations that arise during cancer progression and that generate abnormal gene products, activated signal transduction pathways, and altered cancer cell-host stroma interactions can be considered targets of therapeutic drugs. Some of these drugs have already entered clinical trials, while others have shown promising results. In this review, we examine some of the successive steps of the metastatic process: cancer cell migration and invasion of the tumor microenvironment, angiogenesis and following extravasation focusing on the deranged signalling pathways underlying the malignant phenotypes. Finally, the application of new proteomic methodologies to detect cancer earlier and for a patient-tailored therapy are illustrated.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine9
RivistaCurrent Signal Transduction Therapy
Volume4
Stato di pubblicazionePublished - 2009

Fingerprint

Neoplasm Metastasis
Neoplasms
Therapeutics
Tumor Microenvironment
Pharmaceutical Preparations
Proteomics
Cell Movement
Signal Transduction
Phenotype

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Pharmacology (medical)

Cita questo

@article{3c3114fc3b974a06a551b32b3b267e48,
title = "Cancer invasion ad metastasis: discovering new targets for diagnosis and therapeutics",
abstract = "Cancer invasion and metastases are the hallmarks of malignant tumors and the cause of most cancer deaths. Molecular alterations that arise during cancer progression and that generate abnormal gene products, activated signal transduction pathways, and altered cancer cell-host stroma interactions can be considered targets of therapeutic drugs. Some of these drugs have already entered clinical trials, while others have shown promising results. In this review, we examine some of the successive steps of the metastatic process: cancer cell migration and invasion of the tumor microenvironment, angiogenesis and following extravasation focusing on the deranged signalling pathways underlying the malignant phenotypes. Finally, the application of new proteomic methodologies to detect cancer earlier and for a patient-tailored therapy are illustrated.",
keywords = "Tumor invasion; Tumor microenvironment; signal trasduction therapy; angiogenesis; proteomics",
author = "{De Leo}, Giacomo and Riccardo Alessandro and Simona Fontana",
year = "2009",
language = "English",
volume = "4",
pages = "--",
journal = "Current Signal Transduction Therapy",
issn = "1574-3624",
publisher = "Bentham Science Publishers B.V.",

}

TY - JOUR

T1 - Cancer invasion ad metastasis: discovering new targets for diagnosis and therapeutics

AU - De Leo, Giacomo

AU - Alessandro, Riccardo

AU - Fontana, Simona

PY - 2009

Y1 - 2009

N2 - Cancer invasion and metastases are the hallmarks of malignant tumors and the cause of most cancer deaths. Molecular alterations that arise during cancer progression and that generate abnormal gene products, activated signal transduction pathways, and altered cancer cell-host stroma interactions can be considered targets of therapeutic drugs. Some of these drugs have already entered clinical trials, while others have shown promising results. In this review, we examine some of the successive steps of the metastatic process: cancer cell migration and invasion of the tumor microenvironment, angiogenesis and following extravasation focusing on the deranged signalling pathways underlying the malignant phenotypes. Finally, the application of new proteomic methodologies to detect cancer earlier and for a patient-tailored therapy are illustrated.

AB - Cancer invasion and metastases are the hallmarks of malignant tumors and the cause of most cancer deaths. Molecular alterations that arise during cancer progression and that generate abnormal gene products, activated signal transduction pathways, and altered cancer cell-host stroma interactions can be considered targets of therapeutic drugs. Some of these drugs have already entered clinical trials, while others have shown promising results. In this review, we examine some of the successive steps of the metastatic process: cancer cell migration and invasion of the tumor microenvironment, angiogenesis and following extravasation focusing on the deranged signalling pathways underlying the malignant phenotypes. Finally, the application of new proteomic methodologies to detect cancer earlier and for a patient-tailored therapy are illustrated.

KW - Tumor invasion; Tumor microenvironment; signal trasduction therapy; angiogenesis; proteomics

UR - http://hdl.handle.net/10447/37415

M3 - Article

VL - 4

SP - -

JO - Current Signal Transduction Therapy

JF - Current Signal Transduction Therapy

SN - 1574-3624

ER -