Cancer invasion and metastases are the hallmarks of malignant tumors and the cause of most cancerdeaths. Molecular alterations that arise during cancer progression and that generate abnormal geneproducts, activated signal transduction pathways, and altered cancer cell-host stroma interactionscan be considered targets of therapeutic drugs. Some of these drugs have already entered clinicaltrials, while others have shown promising results. In this review, we examine some of the successivesteps of the metastatic process: cancer cell migration and invasion of the tumor microenvironment,angiogenesis and following extravasation focusing on the deranged signalling pathways underlyingthe malignant phenotypes. Finally, the application of new proteomic methodologies to detect cancerearlier and for a patient-tailored therapy are illustrated.
|Numero di pagine||9|
|Rivista||Current Signal Transduction Therapy|
|Stato di pubblicazione||Published - 2009|
All Science Journal Classification (ASJC) codes