INTRODUCTION: The incidence of cancer among residents in sites contaminated bypollutants with a possible health impact is not adequately studied. In Italy,SENTIERI Project (Epidemiological study of residents in National PriorityContaminated Sites, NPCSs) was implemented to study major health outcomes forresidents in 44 NPCSs.METHODS: The Italian Association of Cancer Registries (AIRTUM) records cancerincidence in 23 NPCSs. For each NPCSs, the incidence of all malignant cancerscombined and 35 cancer sites (coded according to ICD-10), was analysed(1996-2005). The observed cases were compared to the expected based on age(5-year period,18 classes), gender, calendar period (1996-2000; 2001-2005),geographical area (North-Centre and Centre-South) and cancer sites specificrates. Standardized Incidence Ratios (SIR) with 90% Confidence Intervals werecomputed.RESULTS: In both genders an excess was observed for overall cancer incidence (9% in men and 7% in women) as well as for specific cancer sites (colon and rectum,liver, gallblad-der, pancreas, lung, skin melanoma, bladder and Non Hodgkinlymphoma). Deficits were observed for gastric cancer in both genders, chroniclymphoid leukemia (men), malignant thyroid neoplasms, corpus uteri and connectiveand soft-tissue tumours and sarcomas (women).DISCUSSION: This report is, to our knowledge, the first one on cancer risk ofresidents in NPCSs. The study, although not aiming to estimate the cancer burden attributable to the environment as compared to occupation or life-style, supportsthe credibility of an etiologic role of environmental exposures in contaminatedsites. Ongoing analyses focus on the interpretation of risk factors for excesses of specific cancer types overall and in specific NPCSs in relation to thepresence of carcinogenic pollutants.
- Public Health, Environmental and Occupational Health