Cancer incidence in Italian contaminated sites

Francesco Vitale, Catelan, Binazzi, Minerba, Emanuele Crocetti, Emanuele Crocetti, Manno, Nicita, Magoni, Falleni, Piccardi, Scaini, Carere, Fortunato Bianconi, Tisano, Paolo Ricci, Ricci, Stefano Ferretti, Stefano Ferretti, De SantisPisani, Benedetti, Candela, Sechi, Conti, Maspero, Usala, Pietro Comba, Pietro Comba, Carlotta Buzzoni, Carlotta Buzzoni, Grisotto, Amerigo Zona, Stefano Guzzinati, Luigi Cremone, Gola, Lillini, Mario Fusco, Fusco, Fabio Pannozzo, La Rosa, Coviello, Mazzoleni, A. Sutera Sardo, Vercelli, Dei Tos, Giacomin, Guzzinati, Cremone, Paolo Ricci, Ricci, Sechi, Cremone, Marcello, Corfiati, Susanna Vitarelli, Marinaccio, Roberto Pasetto, Roberto Pasetto, Soggiu, Madeddu, Milena Maule, Autelitano, Ivano Iavarone, Ivano Iavarone, Stracci, Beccaloni, Cocchioni, Lucia Mangone, Silvano Piffer, Salvatore Sciacca, Giovanna Tagliabue, Roberta Pirastu, Roberta Pirastu, Francesco Vitale, Dei Tos, Zambon, Marsili, Ettore Bidoli, Fabio Falcini, Mario Fusco, Mario Fusco, Diego Serraino, Biggeri, Merletti, Massimo Federico, Bruno, Santoro, Minelli, Michiara, Lucia Fazzo, Lucia Fazzo, Benfatto

Risultato della ricerca: Articlepeer review

26 Citazioni (Scopus)

Abstract

INTRODUCTION: The incidence of cancer among residents in sites contaminated bypollutants with a possible health impact is not adequately studied. In Italy,SENTIERI Project (Epidemiological study of residents in National PriorityContaminated Sites, NPCSs) was implemented to study major health outcomes forresidents in 44 NPCSs.METHODS: The Italian Association of Cancer Registries (AIRTUM) records cancerincidence in 23 NPCSs. For each NPCSs, the incidence of all malignant cancerscombined and 35 cancer sites (coded according to ICD-10), was analysed(1996-2005). The observed cases were compared to the expected based on age(5-year period,18 classes), gender, calendar period (1996-2000; 2001-2005),geographical area (North-Centre and Centre-South) and cancer sites specificrates. Standardized Incidence Ratios (SIR) with 90% Confidence Intervals werecomputed.RESULTS: In both genders an excess was observed for overall cancer incidence (9% in men and 7% in women) as well as for specific cancer sites (colon and rectum,liver, gallblad-der, pancreas, lung, skin melanoma, bladder and Non Hodgkinlymphoma). Deficits were observed for gastric cancer in both genders, chroniclymphoid leukemia (men), malignant thyroid neoplasms, corpus uteri and connectiveand soft-tissue tumours and sarcomas (women).DISCUSSION: This report is, to our knowledge, the first one on cancer risk ofresidents in NPCSs. The study, although not aiming to estimate the cancer burden attributable to the environment as compared to occupation or life-style, supportsthe credibility of an etiologic role of environmental exposures in contaminatedsites. Ongoing analyses focus on the interpretation of risk factors for excesses of specific cancer types overall and in specific NPCSs in relation to thepresence of carcinogenic pollutants.
Lingua originaleEnglish
pagine (da-a)186-191
Numero di pagine6
RivistaANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ
Volume50
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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