Cancer growth dynamics: stochastic models and noise induced effects

Nicola Pizzolato, Bernardo Spagnolo, Dominique Persano Adorno, Alessandro Fiasconaro, Davide Valenti, Pizzolato, Caldara, Ewa Gudowska-Nowak, D. Persano Adorno, Spagnolo, Davide Valenti, Ochab-Marcinek, Alessandro Fiasconaro, Pasquale Caldara

Risultato della ricerca: Otherpeer review

3 Citazioni (Scopus)

Abstract

In the framework of the Michaelis-Menten (MM) reaction kinetics, we analyze thecancer growth dynamics in the presence of the immune response. We found the coexistence of noise enhanced stability (NES) and resonant activation (RA) phenomena which act in an opposite way with respect to the extinction of the tumor The role of the stochastic resonance (SR) in the case of weak cancer therapy has been analyzed. The evolutionary dynamics of a system of cancerous cells in a model of chronic myeloid leukemia (CML) is investigated by a Monte Carlo approach. Weanalyzed the effects of a targeted therapy on the evolutionary dynamics of normal, first-mutant and cancerous cell populations. We show how the patient response to the therapy changes when an high value of the mutation rate from healthy to cancerous cells is present. Our results are in agreement with clinical observations.
Lingua originaleEnglish
Pagine539-544
Numero di pagine6
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.3100.3100???

Fingerprint Entra nei temi di ricerca di 'Cancer growth dynamics: stochastic models and noise induced effects'. Insieme formano una fingerprint unica.

Cita questo