Cancer and the microbiome: Potential applications as new tumor biomarker

Marta Castiglia, Antonio Russo, Giuseppe Bronte, Francesco Passiglia, Ignacio Gil-Bazo, Marc Peeters, Marta Castiglia, Francesco Passiglia, Khan Shahanavaj, Anna P Carreca, Christian Rolfo, José Luis Del Pozo, Christian Diego Rolfo

Risultato della ricerca: Article

23 Citazioni (Scopus)

Abstract

Microbial communities that colonize in humans are collectively described as microbiome. According to conservative estimates, about 15% of all types of neoplasms are related to different infective agents. However, current knowledge is not sufficient to explain how the microbiome contributes to the growth and development of cancers. Large and thorough studies involving colonized, diverse and complex microbiome entities are required to identify microbiome as a potential cancer marker and to understand how the immune system is involved in response to pathogens. This article reviews the existing evidence supporting the enigmatic association of transformed microbiome with the development of cancer through the immunological modification. Ascertaining the connection between microbiome and immunological responses with risk of cancer may direct to explaining significant advances in the etiology of cancer, potentially disclosing a novel paradigm of research for the management and prevention of cancer.
Lingua originaleEnglish
pagine (da-a)317-330
Numero di pagine14
RivistaExpert Review of Anticancer Therapy
Volume15
Stato di pubblicazionePublished - 2015

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology (medical)

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Castiglia, M., Russo, A., Bronte, G., Passiglia, F., Gil-Bazo, I., Peeters, M., Castiglia, M., Passiglia, F., Shahanavaj, K., Carreca, A. P., Rolfo, C., Del Pozo, J. L., & Rolfo, C. D. (2015). Cancer and the microbiome: Potential applications as new tumor biomarker. Expert Review of Anticancer Therapy, 15, 317-330.