Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study

Vito Chiantera, Vito Chiantera, Pierandrea De Iaco, Enrico Vizza, Alfredo Ercoli, Francesco Fanfani, Anna Fagotti, Gabriella Ferrandina, Giovanni Scambia, Giacomo Corrado, Valerio Gallotta, Carolina Bottoni, Luigi Pedone Anchora

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Background: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM). Our objective is to define a precise risk of LNM for each ECC patient in order to significantly tailor surgery for ECC. Methods: Clinical and pathological data of ECC patients were retrospectively collected by eight Italian institutions. Chi-square test or Fisher’s exact test along with logistic regression analysis was used to determine the association of each variable between patients with or without LNM. Results of logistic regression have been used as a basis to calculate the probability to harboring LNM. Results: A total of 463 ECC patients were identified. No LNM was detected among the 161 (34.8%) patients who met the criteria and were defined as Very Low Risk. In the other 302 patients, the precise risk of LNM was calculated, and it was <1% in 31 (10.3%) patients. Conclusions: Defining the precise risk of LNM could lead to proper selection of patients in whom any lymph nodal procedure, including SLN, could be avoided.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine8
RivistaAnnals of Surgical Oncology
Stato di pubblicazionePublished - 2017

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Uterine Cervical Neoplasms
Retrospective Studies
Lymph Nodes
Neoplasm Metastasis
Lymph Node Excision
Logistic Models
Sentinel Lymph Node Biopsy
Lymph
Chi-Square Distribution
Patient Selection
Regression Analysis
Guidelines

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cita questo

Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study. / Chiantera, Vito; Chiantera, Vito; De Iaco, Pierandrea; Vizza, Enrico; Ercoli, Alfredo; Fanfani, Francesco; Fagotti, Anna; Ferrandina, Gabriella; Scambia, Giovanni; Corrado, Giacomo; Gallotta, Valerio; Bottoni, Carolina; Pedone Anchora, Luigi.

In: Annals of Surgical Oncology, 2017, pag. -.

Risultato della ricerca: Article

Chiantera, V, Chiantera, V, De Iaco, P, Vizza, E, Ercoli, A, Fanfani, F, Fagotti, A, Ferrandina, G, Scambia, G, Corrado, G, Gallotta, V, Bottoni, C & Pedone Anchora, L 2017, 'Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study', Annals of Surgical Oncology, pagg. -.
Chiantera, Vito ; Chiantera, Vito ; De Iaco, Pierandrea ; Vizza, Enrico ; Ercoli, Alfredo ; Fanfani, Francesco ; Fagotti, Anna ; Ferrandina, Gabriella ; Scambia, Giovanni ; Corrado, Giacomo ; Gallotta, Valerio ; Bottoni, Carolina ; Pedone Anchora, Luigi. / Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study. In: Annals of Surgical Oncology. 2017 ; pagg. -.
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title = "Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study",
abstract = "Background: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM). Our objective is to define a precise risk of LNM for each ECC patient in order to significantly tailor surgery for ECC. Methods: Clinical and pathological data of ECC patients were retrospectively collected by eight Italian institutions. Chi-square test or Fisher’s exact test along with logistic regression analysis was used to determine the association of each variable between patients with or without LNM. Results of logistic regression have been used as a basis to calculate the probability to harboring LNM. Results: A total of 463 ECC patients were identified. No LNM was detected among the 161 (34.8{\%}) patients who met the criteria and were defined as Very Low Risk. In the other 302 patients, the precise risk of LNM was calculated, and it was <1{\%} in 31 (10.3{\%}) patients. Conclusions: Defining the precise risk of LNM could lead to proper selection of patients in whom any lymph nodal procedure, including SLN, could be avoided.",
author = "Vito Chiantera and Vito Chiantera and {De Iaco}, Pierandrea and Enrico Vizza and Alfredo Ercoli and Francesco Fanfani and Anna Fagotti and Gabriella Ferrandina and Giovanni Scambia and Giacomo Corrado and Valerio Gallotta and Carolina Bottoni and {Pedone Anchora}, Luigi",
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T1 - Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study

AU - Chiantera, Vito

AU - Chiantera, Vito

AU - De Iaco, Pierandrea

AU - Vizza, Enrico

AU - Ercoli, Alfredo

AU - Fanfani, Francesco

AU - Fagotti, Anna

AU - Ferrandina, Gabriella

AU - Scambia, Giovanni

AU - Corrado, Giacomo

AU - Gallotta, Valerio

AU - Bottoni, Carolina

AU - Pedone Anchora, Luigi

PY - 2017

Y1 - 2017

N2 - Background: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM). Our objective is to define a precise risk of LNM for each ECC patient in order to significantly tailor surgery for ECC. Methods: Clinical and pathological data of ECC patients were retrospectively collected by eight Italian institutions. Chi-square test or Fisher’s exact test along with logistic regression analysis was used to determine the association of each variable between patients with or without LNM. Results of logistic regression have been used as a basis to calculate the probability to harboring LNM. Results: A total of 463 ECC patients were identified. No LNM was detected among the 161 (34.8%) patients who met the criteria and were defined as Very Low Risk. In the other 302 patients, the precise risk of LNM was calculated, and it was <1% in 31 (10.3%) patients. Conclusions: Defining the precise risk of LNM could lead to proper selection of patients in whom any lymph nodal procedure, including SLN, could be avoided.

AB - Background: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM). Our objective is to define a precise risk of LNM for each ECC patient in order to significantly tailor surgery for ECC. Methods: Clinical and pathological data of ECC patients were retrospectively collected by eight Italian institutions. Chi-square test or Fisher’s exact test along with logistic regression analysis was used to determine the association of each variable between patients with or without LNM. Results of logistic regression have been used as a basis to calculate the probability to harboring LNM. Results: A total of 463 ECC patients were identified. No LNM was detected among the 161 (34.8%) patients who met the criteria and were defined as Very Low Risk. In the other 302 patients, the precise risk of LNM was calculated, and it was <1% in 31 (10.3%) patients. Conclusions: Defining the precise risk of LNM could lead to proper selection of patients in whom any lymph nodal procedure, including SLN, could be avoided.

UR - http://hdl.handle.net/10447/239437

M3 - Article

SP - -

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

ER -