Can side-specific biopsy findings predict the side of nodal metastasis in clinically localized prostate cancer? Results from a multicenter prospective survey

Francesca Maria Carini, Alchiede Simonato, Riccardo Schiavina, Capitanio, Marco Borghesi, Eugenio Brunocilla, Mauro Gacci, Alchiede Simonato, Ciro Imbimbo, Vincenzo Mirone, Giuseppe Martorana, Giorgio Carmignani, Francesco Montorsi, Marco Carini, Alberto Briganti, Annunziata Briganti

Risultato della ricerca: Article

2 Citazioni (Scopus)

Abstract

Background To evaluate the correlation between the side of positive biopsy (Bx) and the risk of lymph-node metastases (LNMs) on each side and to quantify the risk of contralateral LNMs in patients with unilateral positive biopsy. Methods We analyzed the outcomes of 1599 patients with complete data regarding the sides of positive Bx and LN (lymph-node). By dividing each prostate into two separate sides, we assessed the accuracy of the side-specific Bx details in determining the side of positive nodes; the area under the receiver-operating characteristic (ROC) (AUCs) was used. For patients with unilateral positive Bx, we assessed the risk of homolateral and contralateral LNMs according to the number of total Bx taken and the preoperative risk of LN invasion. Results Considering the 3198 prostate sides, there was a strict correlation between the side of positive Bx and the side of LNMs. The ratio of positive/total Bx was more informative than the number of positive core. The AUC for ipsilateral LNMs was significantly higher than that for contralateral LNMs (P = 0.039). In the 805 patients with unilateral positive Bx, the percentage of contralateral LNMs was >30% even considering a more meticulous biopsy scheme and increased in the patients at a higher clinical risk for LN invasion. Conclusion PCa preferentially metastasizes to ipsilateral LNs but >30% of contralateral LNMs are present. A unilateral LN dissection that is limited to the tumor-bearing side of the gland should not be recommended because of the substantial risk of missing contralateral metastases. © 2013 Elsevier Ltd. All rights reserved.
Lingua originaleEnglish
pagine (da-a)1019-1024
Numero di pagine6
RivistaEuropean Journal of Surgical Oncology
Volume39
Stato di pubblicazionePublished - 2013

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Prostatic Neoplasms
Lymph Nodes
Neoplasm Metastasis
Biopsy
Area Under Curve
Prostate
Surveys and Questionnaires
Lymph Node Excision
ROC Curve

All Science Journal Classification (ASJC) codes

  • Oncology
  • Surgery

Cita questo

Can side-specific biopsy findings predict the side of nodal metastasis in clinically localized prostate cancer? Results from a multicenter prospective survey. / Carini, Francesca Maria; Simonato, Alchiede; Schiavina, Riccardo; Capitanio; Borghesi, Marco; Brunocilla, Eugenio; Gacci, Mauro; Simonato, Alchiede; Imbimbo, Ciro; Mirone, Vincenzo; Martorana, Giuseppe; Carmignani, Giorgio; Montorsi, Francesco; Carini, Marco; Briganti, Alberto; Briganti, Annunziata.

In: European Journal of Surgical Oncology, Vol. 39, 2013, pag. 1019-1024.

Risultato della ricerca: Article

Carini, FM, Simonato, A, Schiavina, R, Capitanio, Borghesi, M, Brunocilla, E, Gacci, M, Simonato, A, Imbimbo, C, Mirone, V, Martorana, G, Carmignani, G, Montorsi, F, Carini, M, Briganti, A & Briganti, A 2013, 'Can side-specific biopsy findings predict the side of nodal metastasis in clinically localized prostate cancer? Results from a multicenter prospective survey', European Journal of Surgical Oncology, vol. 39, pagg. 1019-1024.
Carini, Francesca Maria ; Simonato, Alchiede ; Schiavina, Riccardo ; Capitanio ; Borghesi, Marco ; Brunocilla, Eugenio ; Gacci, Mauro ; Simonato, Alchiede ; Imbimbo, Ciro ; Mirone, Vincenzo ; Martorana, Giuseppe ; Carmignani, Giorgio ; Montorsi, Francesco ; Carini, Marco ; Briganti, Alberto ; Briganti, Annunziata. / Can side-specific biopsy findings predict the side of nodal metastasis in clinically localized prostate cancer? Results from a multicenter prospective survey. In: European Journal of Surgical Oncology. 2013 ; Vol. 39. pagg. 1019-1024.
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title = "Can side-specific biopsy findings predict the side of nodal metastasis in clinically localized prostate cancer? Results from a multicenter prospective survey",
abstract = "Background To evaluate the correlation between the side of positive biopsy (Bx) and the risk of lymph-node metastases (LNMs) on each side and to quantify the risk of contralateral LNMs in patients with unilateral positive biopsy. Methods We analyzed the outcomes of 1599 patients with complete data regarding the sides of positive Bx and LN (lymph-node). By dividing each prostate into two separate sides, we assessed the accuracy of the side-specific Bx details in determining the side of positive nodes; the area under the receiver-operating characteristic (ROC) (AUCs) was used. For patients with unilateral positive Bx, we assessed the risk of homolateral and contralateral LNMs according to the number of total Bx taken and the preoperative risk of LN invasion. Results Considering the 3198 prostate sides, there was a strict correlation between the side of positive Bx and the side of LNMs. The ratio of positive/total Bx was more informative than the number of positive core. The AUC for ipsilateral LNMs was significantly higher than that for contralateral LNMs (P = 0.039). In the 805 patients with unilateral positive Bx, the percentage of contralateral LNMs was >30{\%} even considering a more meticulous biopsy scheme and increased in the patients at a higher clinical risk for LN invasion. Conclusion PCa preferentially metastasizes to ipsilateral LNs but >30{\%} of contralateral LNMs are present. A unilateral LN dissection that is limited to the tumor-bearing side of the gland should not be recommended because of the substantial risk of missing contralateral metastases. {\circledC} 2013 Elsevier Ltd. All rights reserved.",
author = "Carini, {Francesca Maria} and Alchiede Simonato and Riccardo Schiavina and Capitanio and Marco Borghesi and Eugenio Brunocilla and Mauro Gacci and Alchiede Simonato and Ciro Imbimbo and Vincenzo Mirone and Giuseppe Martorana and Giorgio Carmignani and Francesco Montorsi and Marco Carini and Alberto Briganti and Annunziata Briganti",
year = "2013",
language = "English",
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journal = "European Journal of Surgical Oncology",
issn = "0748-7983",
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T1 - Can side-specific biopsy findings predict the side of nodal metastasis in clinically localized prostate cancer? Results from a multicenter prospective survey

AU - Carini, Francesca Maria

AU - Simonato, Alchiede

AU - Schiavina, Riccardo

AU - Capitanio, null

AU - Borghesi, Marco

AU - Brunocilla, Eugenio

AU - Gacci, Mauro

AU - Simonato, Alchiede

AU - Imbimbo, Ciro

AU - Mirone, Vincenzo

AU - Martorana, Giuseppe

AU - Carmignani, Giorgio

AU - Montorsi, Francesco

AU - Carini, Marco

AU - Briganti, Alberto

AU - Briganti, Annunziata

PY - 2013

Y1 - 2013

N2 - Background To evaluate the correlation between the side of positive biopsy (Bx) and the risk of lymph-node metastases (LNMs) on each side and to quantify the risk of contralateral LNMs in patients with unilateral positive biopsy. Methods We analyzed the outcomes of 1599 patients with complete data regarding the sides of positive Bx and LN (lymph-node). By dividing each prostate into two separate sides, we assessed the accuracy of the side-specific Bx details in determining the side of positive nodes; the area under the receiver-operating characteristic (ROC) (AUCs) was used. For patients with unilateral positive Bx, we assessed the risk of homolateral and contralateral LNMs according to the number of total Bx taken and the preoperative risk of LN invasion. Results Considering the 3198 prostate sides, there was a strict correlation between the side of positive Bx and the side of LNMs. The ratio of positive/total Bx was more informative than the number of positive core. The AUC for ipsilateral LNMs was significantly higher than that for contralateral LNMs (P = 0.039). In the 805 patients with unilateral positive Bx, the percentage of contralateral LNMs was >30% even considering a more meticulous biopsy scheme and increased in the patients at a higher clinical risk for LN invasion. Conclusion PCa preferentially metastasizes to ipsilateral LNs but >30% of contralateral LNMs are present. A unilateral LN dissection that is limited to the tumor-bearing side of the gland should not be recommended because of the substantial risk of missing contralateral metastases. © 2013 Elsevier Ltd. All rights reserved.

AB - Background To evaluate the correlation between the side of positive biopsy (Bx) and the risk of lymph-node metastases (LNMs) on each side and to quantify the risk of contralateral LNMs in patients with unilateral positive biopsy. Methods We analyzed the outcomes of 1599 patients with complete data regarding the sides of positive Bx and LN (lymph-node). By dividing each prostate into two separate sides, we assessed the accuracy of the side-specific Bx details in determining the side of positive nodes; the area under the receiver-operating characteristic (ROC) (AUCs) was used. For patients with unilateral positive Bx, we assessed the risk of homolateral and contralateral LNMs according to the number of total Bx taken and the preoperative risk of LN invasion. Results Considering the 3198 prostate sides, there was a strict correlation between the side of positive Bx and the side of LNMs. The ratio of positive/total Bx was more informative than the number of positive core. The AUC for ipsilateral LNMs was significantly higher than that for contralateral LNMs (P = 0.039). In the 805 patients with unilateral positive Bx, the percentage of contralateral LNMs was >30% even considering a more meticulous biopsy scheme and increased in the patients at a higher clinical risk for LN invasion. Conclusion PCa preferentially metastasizes to ipsilateral LNs but >30% of contralateral LNMs are present. A unilateral LN dissection that is limited to the tumor-bearing side of the gland should not be recommended because of the substantial risk of missing contralateral metastases. © 2013 Elsevier Ltd. All rights reserved.

UR - http://hdl.handle.net/10447/353431

M3 - Article

VL - 39

SP - 1019

EP - 1024

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

SN - 0748-7983

ER -