Can radium 223 be a conservative non-surgical management of medication-related osteonecrosis of the jaw?

Risultato della ricerca: Article

Abstract

Osteonecrosis of the jaw (ONJ) is a rare and severe necrotic bone disease reflecting a compromise in the body's osseous healing mechanisms and unique to the craniofacial region. Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In 2018, a Caucasian 54-year-old woman presented to our institution for a breast cancer with bone metastases. Since the patient refused any treatment and taking into account the bone disease, our multidisciplinary team evaluated a supplementary strategy with radium 223. A total of six treatments were planned with a dose of 50 KBq/kg every 4 weeks according to Phase 2 data. Four days after the second cycle administration, the patient presented for examination with a self-extracted necrotic bone fragment. Oroantral communication remained in the absence of algic symptomatology or suppuration. The multidisciplinary approach between oncologists, nuclear physicians, and dental health teams is crucial throughout the treatment process to avoid unnecessary suffering in patients at risk. More prospective studies are needed; however, considering the limitation of the present case, radio 223 may play an adjuvant role in the medical treatment of cancer patients with active ONJ.
Lingua originaleEnglish
pagine (da-a)307-309-
Numero di pagine3
RivistaWORLD JOURNAL OF NUCLEAR MEDICINE
Volume18
Stato di pubblicazionePublished - 2019

Fingerprint

Radium
Osteonecrosis
Jaw
Bone Diseases
Neoplasm Metastasis
Prostatic Neoplasms
Therapeutics
Bone and Bones
Bone Neoplasms
Suppuration
Radio
Psychological Stress
Tooth
Communication
Prospective Studies
Breast Neoplasms
Physicians
Survival
Health
Neoplasms

Cita questo

@article{5e8f8a9957f34825807a67a132858148,
title = "Can radium 223 be a conservative non-surgical management of medication-related osteonecrosis of the jaw?",
abstract = "Osteonecrosis of the jaw (ONJ) is a rare and severe necrotic bone disease reflecting a compromise in the body's osseous healing mechanisms and unique to the craniofacial region. Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In 2018, a Caucasian 54-year-old woman presented to our institution for a breast cancer with bone metastases. Since the patient refused any treatment and taking into account the bone disease, our multidisciplinary team evaluated a supplementary strategy with radium 223. A total of six treatments were planned with a dose of 50 KBq/kg every 4 weeks according to Phase 2 data. Four days after the second cycle administration, the patient presented for examination with a self-extracted necrotic bone fragment. Oroantral communication remained in the absence of algic symptomatology or suppuration. The multidisciplinary approach between oncologists, nuclear physicians, and dental health teams is crucial throughout the treatment process to avoid unnecessary suffering in patients at risk. More prospective studies are needed; however, considering the limitation of the present case, radio 223 may play an adjuvant role in the medical treatment of cancer patients with active ONJ.",
keywords = "Bone metastases, breast cancer, osteonecrosis of the jaw, radium 223",
author = "Rodolfo Mauceri and Antonio Pinto and Giuseppina Campisi and Licari, {Chiara Maria}",
year = "2019",
language = "English",
volume = "18",
pages = "307--309--",
journal = "WORLD JOURNAL OF NUCLEAR MEDICINE",
issn = "1450-1147",

}

TY - JOUR

T1 - Can radium 223 be a conservative non-surgical management of medication-related osteonecrosis of the jaw?

AU - Mauceri, Rodolfo

AU - Pinto, Antonio

AU - Campisi, Giuseppina

AU - Licari, Chiara Maria

PY - 2019

Y1 - 2019

N2 - Osteonecrosis of the jaw (ONJ) is a rare and severe necrotic bone disease reflecting a compromise in the body's osseous healing mechanisms and unique to the craniofacial region. Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In 2018, a Caucasian 54-year-old woman presented to our institution for a breast cancer with bone metastases. Since the patient refused any treatment and taking into account the bone disease, our multidisciplinary team evaluated a supplementary strategy with radium 223. A total of six treatments were planned with a dose of 50 KBq/kg every 4 weeks according to Phase 2 data. Four days after the second cycle administration, the patient presented for examination with a self-extracted necrotic bone fragment. Oroantral communication remained in the absence of algic symptomatology or suppuration. The multidisciplinary approach between oncologists, nuclear physicians, and dental health teams is crucial throughout the treatment process to avoid unnecessary suffering in patients at risk. More prospective studies are needed; however, considering the limitation of the present case, radio 223 may play an adjuvant role in the medical treatment of cancer patients with active ONJ.

AB - Osteonecrosis of the jaw (ONJ) is a rare and severe necrotic bone disease reflecting a compromise in the body's osseous healing mechanisms and unique to the craniofacial region. Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In 2018, a Caucasian 54-year-old woman presented to our institution for a breast cancer with bone metastases. Since the patient refused any treatment and taking into account the bone disease, our multidisciplinary team evaluated a supplementary strategy with radium 223. A total of six treatments were planned with a dose of 50 KBq/kg every 4 weeks according to Phase 2 data. Four days after the second cycle administration, the patient presented for examination with a self-extracted necrotic bone fragment. Oroantral communication remained in the absence of algic symptomatology or suppuration. The multidisciplinary approach between oncologists, nuclear physicians, and dental health teams is crucial throughout the treatment process to avoid unnecessary suffering in patients at risk. More prospective studies are needed; however, considering the limitation of the present case, radio 223 may play an adjuvant role in the medical treatment of cancer patients with active ONJ.

KW - Bone metastases

KW - breast cancer

KW - osteonecrosis of the jaw

KW - radium 223

UR - http://hdl.handle.net/10447/377685

M3 - Article

VL - 18

SP - 307-309-

JO - WORLD JOURNAL OF NUCLEAR MEDICINE

JF - WORLD JOURNAL OF NUCLEAR MEDICINE

SN - 1450-1147

ER -