Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study

Michele D'Arienzo, Domenico Costantino Aloj, Mattia Fortina, Stefania Setti, Giuseppe Sessa, Antonio Capone, Matteo Cadossi, Pierluigi Antinolfi, Claudio Cusumano, Leo Massari, Ciro Villani, Antonio Pastrone, Alberto Riva, Vincenzo Lorusso, Dario Dell'Omo, Giuseppe Marongiu, Pietro Maniscalco, Matteo Ghiara, Auro Caraffa, Marco GuidiFilippo La Cava, Roberto Rossi, Alberto Momoli, Attilio Rota, Giovanni Giordano, Ruggero Cadossi, Pier Luigi De Palma, Giovanni Maraglino, M'Putu Bulabula, Carlo De Roberto, Danilo Castellano, Claudio Cusumano, Rossano Stefano Cornacchia, Antonio Giannini, Michele Giudici, Mariano Borrelli, Marco Ranellucci, Ettore Demattè, Guglielmo Abate, Carmelo Scialabba, Guido Bassi, Ugo Baschieri, Silvio Demitri, Pietro Corsi, Raffaele Fontana, Paolo Friemel, Antonio Barile, Stefano Gherardi, Claudio Severino, Patrizio Caldora, Alberto Belluati, Pierluigi Antinolfi, Luigi Ciolli, Auro Caraffa, Giovanni Giordano, Claudio Castelli, Silvio Demitri, Bruno Di Maggio, Pier Giorgio Londini, Andrea Micaglio, Venceslao Tovaglia, Luigi Branca Vergano, Luciano Costarella, Luigi Ciolli, Vincenzo Caiaffa, Vincenzo Zottola, Patrizio Caldora, Dario Perugia, Enrico Castaman, Francesco Lijoi, Luca Pietrogrande, Pier Bruno Squarzina, Mauro Monesi, Francesco Falez, Francesca De Terlizzi, Pietro Persiani, Giuseppe Solarino, Fabio Catani, Biagio Moretti, Antonio Pompilio Gigante, Filippo Castoldi, Francesco Benazzo, Claudio Castelli, Michelangelo Scaglione, Sandro Giannini, Gaetano Caruso, Raffaele Fontana, Silvio Demitri, Alessandra La Gattuta, Claudio Cusumano, Pietro Maniscalco

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

Background. Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time. Methods. The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain. Results. 319 fractures (88%) healed within 12 months from treatment. Forty-four fractures healed after 12 months or underwent a second surgery. FRACTING score positively correlated with days to healing: r = 0.63 (p < 0.0001). Average score value was 7.3 ± 2.5; ROC analysis showed strong reliability of the score in separating patients healing before versus after 6 months: AUC = 0.823. Conclusions. This study shows that the FRACTING score can be employed both to predict months needed for fracture healing and to identify immediately after treatment patients at risk of prolonged healing. In patients with high score values, new pharmacological and nonpharmacological treatments to enhance osteogenesis could be tested selectively, which may finally result in reduced disability time and health cost savings.
Lingua originaleEnglish
Numero di pagine0
RivistaBioMed Research International
Volume2018
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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