Cactus pear fruit extract exerts anti-inflammatory effects in carrageenin-induced rat pleurisy

Risultato della ricerca: Article

Abstract

Nutritional research has recently shifted from alleviating nutrient deficiencies to chronic disease prevention. In this study activity of cactus pear fruit extract (CPFE) from Opuntia ficus-indica (L.) Mill. has been investigated in carrageenin-induced pleurisy, a rat model of acute inflammation. In our experimental design rat pleurisy was achieved by the injection of 0.2 ml of λ-carrageenin in the pleural cavity. At selected time points, rats were sacrificed; cells recruited in pleura were counted and exudates collected to analyse inflammatory parameters such as NO, PGE2, IL-1β, TNF-α. CPFE (in the range between 5 and 20 g fresh fruit equivalent/kg), orally given 30 min before the injection, time- and dose-dependently reduced the exudate volume (up to 72%) and the number of leukocytes recruited in the pleural cavity (up to 96%), at 24 h. These anti-inflammatory effects were accompanied by an inhibited release of inflammatory mediators (PGE2, NO, IL-1β, TNF-α). Our in vivo findings unveil for the first time an anti-inflammatory potential for cactus pear fruit and suggest further investigations to propose cactus pear fruit as a functional food able to improve health, possibly by preventing inflammation-based disorders. © 2015, International Society for Horticultural Science. All rights reserved.
Lingua originaleEnglish
pagine (da-a)19-25
Numero di pagine7
RivistaACTA HORTICULTURAE
Volume1067
Stato di pubblicazionePublished - 2015

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cactus pears
fruit extracts
carrageenan
anti-inflammatory activity
rats
interleukin-1
inflammation
injection
pleura
Opuntia ficus-indica
fruits
disease prevention
nutrient deficiencies
raw fruit
chronic diseases
leukocyte count
functional foods
animal models
experimental design
pleurisy

All Science Journal Classification (ASJC) codes

  • Horticulture

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title = "Cactus pear fruit extract exerts anti-inflammatory effects in carrageenin-induced rat pleurisy",
abstract = "Nutritional research has recently shifted from alleviating nutrient deficiencies to chronic disease prevention. In this study activity of cactus pear fruit extract (CPFE) from Opuntia ficus-indica (L.) Mill. has been investigated in carrageenin-induced pleurisy, a rat model of acute inflammation. In our experimental design rat pleurisy was achieved by the injection of 0.2 ml of λ-carrageenin in the pleural cavity. At selected time points, rats were sacrificed; cells recruited in pleura were counted and exudates collected to analyse inflammatory parameters such as NO, PGE2, IL-1β, TNF-α. CPFE (in the range between 5 and 20 g fresh fruit equivalent/kg), orally given 30 min before the injection, time- and dose-dependently reduced the exudate volume (up to 72{\%}) and the number of leukocytes recruited in the pleural cavity (up to 96{\%}), at 24 h. These anti-inflammatory effects were accompanied by an inhibited release of inflammatory mediators (PGE2, NO, IL-1β, TNF-α). Our in vivo findings unveil for the first time an anti-inflammatory potential for cactus pear fruit and suggest further investigations to propose cactus pear fruit as a functional food able to improve health, possibly by preventing inflammation-based disorders. {\circledC} 2015, International Society for Horticultural Science. All rights reserved.",
author = "Mario Allegra and Luisa Tesoriere and Livrea, {Maria Antonia} and Panza and Ianaro",
year = "2015",
language = "English",
volume = "1067",
pages = "19--25",
journal = "ACTA HORTICULTURAE",
issn = "0567-7572",

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TY - JOUR

T1 - Cactus pear fruit extract exerts anti-inflammatory effects in carrageenin-induced rat pleurisy

AU - Allegra, Mario

AU - Tesoriere, Luisa

AU - Livrea, Maria Antonia

AU - Panza, null

AU - Ianaro, null

PY - 2015

Y1 - 2015

N2 - Nutritional research has recently shifted from alleviating nutrient deficiencies to chronic disease prevention. In this study activity of cactus pear fruit extract (CPFE) from Opuntia ficus-indica (L.) Mill. has been investigated in carrageenin-induced pleurisy, a rat model of acute inflammation. In our experimental design rat pleurisy was achieved by the injection of 0.2 ml of λ-carrageenin in the pleural cavity. At selected time points, rats were sacrificed; cells recruited in pleura were counted and exudates collected to analyse inflammatory parameters such as NO, PGE2, IL-1β, TNF-α. CPFE (in the range between 5 and 20 g fresh fruit equivalent/kg), orally given 30 min before the injection, time- and dose-dependently reduced the exudate volume (up to 72%) and the number of leukocytes recruited in the pleural cavity (up to 96%), at 24 h. These anti-inflammatory effects were accompanied by an inhibited release of inflammatory mediators (PGE2, NO, IL-1β, TNF-α). Our in vivo findings unveil for the first time an anti-inflammatory potential for cactus pear fruit and suggest further investigations to propose cactus pear fruit as a functional food able to improve health, possibly by preventing inflammation-based disorders. © 2015, International Society for Horticultural Science. All rights reserved.

AB - Nutritional research has recently shifted from alleviating nutrient deficiencies to chronic disease prevention. In this study activity of cactus pear fruit extract (CPFE) from Opuntia ficus-indica (L.) Mill. has been investigated in carrageenin-induced pleurisy, a rat model of acute inflammation. In our experimental design rat pleurisy was achieved by the injection of 0.2 ml of λ-carrageenin in the pleural cavity. At selected time points, rats were sacrificed; cells recruited in pleura were counted and exudates collected to analyse inflammatory parameters such as NO, PGE2, IL-1β, TNF-α. CPFE (in the range between 5 and 20 g fresh fruit equivalent/kg), orally given 30 min before the injection, time- and dose-dependently reduced the exudate volume (up to 72%) and the number of leukocytes recruited in the pleural cavity (up to 96%), at 24 h. These anti-inflammatory effects were accompanied by an inhibited release of inflammatory mediators (PGE2, NO, IL-1β, TNF-α). Our in vivo findings unveil for the first time an anti-inflammatory potential for cactus pear fruit and suggest further investigations to propose cactus pear fruit as a functional food able to improve health, possibly by preventing inflammation-based disorders. © 2015, International Society for Horticultural Science. All rights reserved.

UR - http://hdl.handle.net/10447/5217

M3 - Article

VL - 1067

SP - 19

EP - 25

JO - ACTA HORTICULTURAE

JF - ACTA HORTICULTURAE

SN - 0567-7572

ER -