Burden of Crohn's disease: economics and quality of life aspects in Italy.

Mario Cottone, Mario Cottone, Chiara Ottolini, Gino Roberto Corazza, Mauro Caruggi, Zaccaria Rossi, Giorgio Frosini, Giovanni Fornaciari, Nicola Caporaso, Giorgio L. Colombo, Viviano Benedini

Risultato della ricerca: Article

14 Citazioni (Scopus)

Abstract

BACKGROUND: This was a prospective observational study designed to evaluate direct and indirect costs and quality of life for patients with Crohn's disease in Italy from the perspectives of the National Health System and of society.METHODS: A total of 162 male and female subjects aged 18-70 years with Crohn's disease in the active phase and a Crohn's Disease Activity Index score ≥150 were included in the study. Subjects were recruited from 25 Italian centers on a consecutive basis. The study consisted of four visits undertaken every 6 months with a follow-up period of 18 months. The study started on September 1, 2006 and was completed on April 12, 2010. Multivariate analyses were carried out on demographic characteristics, treatment costs based on the prescribed daily dose, resource use and other cost parameters, and changes in quality of life using the EQ5D questionnaire.RESULTS: Cost of illness per subject with Crohn's disease in Italy was estimated to be €15,521 per year, with direct costs representing 76% of total costs. Nonhealth care costs and loss of productivity accounted for 24% of total costs. Societal costs during the first months of enrolment were higher compared with costs in the final months of the study. Quality of life measured by the EQ-5D was 0.558 initially and then increased to 0.739, with a mean value of 0.677 during the enrolment period. The cost of illness was not correlated with age or gender.CONCLUSION: The cost of illness was correlated with quality of life; Crohn's disease had a negative impact on subjects' quality of life, and higher costs corresponded to a lower quality of life as measured with the EQ5D. Drug treatment may improve quality of life and reduce hospitalization costs. Our results appear to be in line with the results of other international cost-of-illness studies
Lingua originaleEnglish
pagine (da-a)209-218
Numero di pagine10
RivistaClinicoEconomics and Outcomes Research
Volume4
Stato di pubblicazionePublished - 2012

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Cost of Illness
Crohn Disease
Italy
Quality of Life
Costs and Cost Analysis
Quality of life
Burden of disease
Economics
Costs
Health Care Costs
Observational Studies
Hospitalization
Multivariate Analysis
Demography
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Economics, Econometrics and Finance (miscellaneous)
  • Health Policy

Cita questo

Cottone, M., Cottone, M., Ottolini, C., Corazza, G. R., Caruggi, M., Rossi, Z., ... Benedini, V. (2012). Burden of Crohn's disease: economics and quality of life aspects in Italy. ClinicoEconomics and Outcomes Research, 4, 209-218.

Burden of Crohn's disease: economics and quality of life aspects in Italy. / Cottone, Mario; Cottone, Mario; Ottolini, Chiara; Corazza, Gino Roberto; Caruggi, Mauro; Rossi, Zaccaria; Frosini, Giorgio; Fornaciari, Giovanni; Caporaso, Nicola; Colombo, Giorgio L.; Benedini, Viviano.

In: ClinicoEconomics and Outcomes Research, Vol. 4, 2012, pag. 209-218.

Risultato della ricerca: Article

Cottone, M, Cottone, M, Ottolini, C, Corazza, GR, Caruggi, M, Rossi, Z, Frosini, G, Fornaciari, G, Caporaso, N, Colombo, GL & Benedini, V 2012, 'Burden of Crohn's disease: economics and quality of life aspects in Italy.', ClinicoEconomics and Outcomes Research, vol. 4, pagg. 209-218.
Cottone M, Cottone M, Ottolini C, Corazza GR, Caruggi M, Rossi Z e altri. Burden of Crohn's disease: economics and quality of life aspects in Italy. ClinicoEconomics and Outcomes Research. 2012;4:209-218.
Cottone, Mario ; Cottone, Mario ; Ottolini, Chiara ; Corazza, Gino Roberto ; Caruggi, Mauro ; Rossi, Zaccaria ; Frosini, Giorgio ; Fornaciari, Giovanni ; Caporaso, Nicola ; Colombo, Giorgio L. ; Benedini, Viviano. / Burden of Crohn's disease: economics and quality of life aspects in Italy. In: ClinicoEconomics and Outcomes Research. 2012 ; Vol. 4. pagg. 209-218.
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abstract = "BACKGROUND: This was a prospective observational study designed to evaluate direct and indirect costs and quality of life for patients with Crohn's disease in Italy from the perspectives of the National Health System and of society.METHODS: A total of 162 male and female subjects aged 18-70 years with Crohn's disease in the active phase and a Crohn's Disease Activity Index score ≥150 were included in the study. Subjects were recruited from 25 Italian centers on a consecutive basis. The study consisted of four visits undertaken every 6 months with a follow-up period of 18 months. The study started on September 1, 2006 and was completed on April 12, 2010. Multivariate analyses were carried out on demographic characteristics, treatment costs based on the prescribed daily dose, resource use and other cost parameters, and changes in quality of life using the EQ5D questionnaire.RESULTS: Cost of illness per subject with Crohn's disease in Italy was estimated to be €15,521 per year, with direct costs representing 76{\%} of total costs. Nonhealth care costs and loss of productivity accounted for 24{\%} of total costs. Societal costs during the first months of enrolment were higher compared with costs in the final months of the study. Quality of life measured by the EQ-5D was 0.558 initially and then increased to 0.739, with a mean value of 0.677 during the enrolment period. The cost of illness was not correlated with age or gender.CONCLUSION: The cost of illness was correlated with quality of life; Crohn's disease had a negative impact on subjects' quality of life, and higher costs corresponded to a lower quality of life as measured with the EQ5D. Drug treatment may improve quality of life and reduce hospitalization costs. Our results appear to be in line with the results of other international cost-of-illness studies",
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T1 - Burden of Crohn's disease: economics and quality of life aspects in Italy.

AU - Cottone, Mario

AU - Cottone, Mario

AU - Ottolini, Chiara

AU - Corazza, Gino Roberto

AU - Caruggi, Mauro

AU - Rossi, Zaccaria

AU - Frosini, Giorgio

AU - Fornaciari, Giovanni

AU - Caporaso, Nicola

AU - Colombo, Giorgio L.

AU - Benedini, Viviano

PY - 2012

Y1 - 2012

N2 - BACKGROUND: This was a prospective observational study designed to evaluate direct and indirect costs and quality of life for patients with Crohn's disease in Italy from the perspectives of the National Health System and of society.METHODS: A total of 162 male and female subjects aged 18-70 years with Crohn's disease in the active phase and a Crohn's Disease Activity Index score ≥150 were included in the study. Subjects were recruited from 25 Italian centers on a consecutive basis. The study consisted of four visits undertaken every 6 months with a follow-up period of 18 months. The study started on September 1, 2006 and was completed on April 12, 2010. Multivariate analyses were carried out on demographic characteristics, treatment costs based on the prescribed daily dose, resource use and other cost parameters, and changes in quality of life using the EQ5D questionnaire.RESULTS: Cost of illness per subject with Crohn's disease in Italy was estimated to be €15,521 per year, with direct costs representing 76% of total costs. Nonhealth care costs and loss of productivity accounted for 24% of total costs. Societal costs during the first months of enrolment were higher compared with costs in the final months of the study. Quality of life measured by the EQ-5D was 0.558 initially and then increased to 0.739, with a mean value of 0.677 during the enrolment period. The cost of illness was not correlated with age or gender.CONCLUSION: The cost of illness was correlated with quality of life; Crohn's disease had a negative impact on subjects' quality of life, and higher costs corresponded to a lower quality of life as measured with the EQ5D. Drug treatment may improve quality of life and reduce hospitalization costs. Our results appear to be in line with the results of other international cost-of-illness studies

AB - BACKGROUND: This was a prospective observational study designed to evaluate direct and indirect costs and quality of life for patients with Crohn's disease in Italy from the perspectives of the National Health System and of society.METHODS: A total of 162 male and female subjects aged 18-70 years with Crohn's disease in the active phase and a Crohn's Disease Activity Index score ≥150 were included in the study. Subjects were recruited from 25 Italian centers on a consecutive basis. The study consisted of four visits undertaken every 6 months with a follow-up period of 18 months. The study started on September 1, 2006 and was completed on April 12, 2010. Multivariate analyses were carried out on demographic characteristics, treatment costs based on the prescribed daily dose, resource use and other cost parameters, and changes in quality of life using the EQ5D questionnaire.RESULTS: Cost of illness per subject with Crohn's disease in Italy was estimated to be €15,521 per year, with direct costs representing 76% of total costs. Nonhealth care costs and loss of productivity accounted for 24% of total costs. Societal costs during the first months of enrolment were higher compared with costs in the final months of the study. Quality of life measured by the EQ-5D was 0.558 initially and then increased to 0.739, with a mean value of 0.677 during the enrolment period. The cost of illness was not correlated with age or gender.CONCLUSION: The cost of illness was correlated with quality of life; Crohn's disease had a negative impact on subjects' quality of life, and higher costs corresponded to a lower quality of life as measured with the EQ5D. Drug treatment may improve quality of life and reduce hospitalization costs. Our results appear to be in line with the results of other international cost-of-illness studies

KW - CROHN S DISEASE.ECONOMICS.QUALITY OF LIFE

UR - http://hdl.handle.net/10447/70905

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410726/pdf/ceor-4-209.pdf

M3 - Article

VL - 4

SP - 209

EP - 218

JO - ClinicoEconomics and Outcomes Research

JF - ClinicoEconomics and Outcomes Research

SN - 1178-6981

ER -