Bronchial epithelial damage after a half-marathon in nonasthmatic amateur runners

Roberta Santagata, Vincenzo Bellia, Alessandra Paterno', Giuseppe Morici, Maria Rosaria Bonsignore, Maria R. Bonsignore, Giuseppe Morici, Loredana Riccobono, Mirella Profita, Anna Bonanno, Laura Chimenti, Laura Riccobono

Risultato della ricerca: Articlepeer review

49 Citazioni (Scopus)

Abstract

Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L857-62. Epub 2010 Apr 2.Bronchial epithelial damage after a half-marathon in nonasthmatic amateur runners.Chimenti L, Morici G, Paternò A, Santagata R, Bonanno A, Profita M, Riccobono L, Bellia V, Bonsignore MR.SourceDept. Biomedico Di Medicina Interna &amp; Specialistica, Section of Pneumology, Univ. of Palermo, Via Trabucco 180, 90146 Palermo, Italy. laurachimenti@yahoo.itAbstractHigh neutrophil counts in induced sputum have been found in nonasthmatic amateur runners at rest and after a marathon, but the pathogenesis of airway neutrophilia in athletes is still poorly understood. Bronchial epithelial damage may occur during intense exercise, as suggested by investigations conducted in endurance-trained mice and competitive human athletes studied under resting conditions. To gain further information on airway changes acutely induced by exercise, airway cell composition, apoptosis, IL-8 concentration in induced sputum, and serum CC-16 level were measured in 15 male amateur runners at rest (baseline) and shortly after a half-marathon. Different from results obtained after a marathon, neutrophil absolute counts were unchanged, whereas bronchial epithelial cell absolute counts and their apoptosis increased significantly (P < 0.01). IL-8 in induced sputum supernatants almost doubled postrace compared with baseline (P < 0.01) and correlated positively with bronchial epithelial cell absolute counts (R(2) = 0.373, P < 0.01). Serum CC-16 significantly increased after all races (P < 0.01). These data show mild bronchial epithelial cell injury acutely induced by intense endurance exercise in humans, extending to large airways the data obtained in peripheral airways of endurance-trained mice. Therefore, neutrophil influx into the airways of athletes may be secondary to bronchial epithelial damage associated with intense exercise.PMID:20363849[PubMed - indexed for MEDLINE]
Lingua originaleEnglish
pagine (da-a)857-862
Numero di pagine6
RivistaAMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Volume298
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

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