Breakthrough pain in oncology: a longitudinal study.

Alessandra Casuccio, Vittorio Gebbia, Carlo Arcara, Gaetano Lanzetta, Enrico Breda, Vittoria Zagonel, Filomena Narducci, Federica Aielli, Virginia Passeri, Fabrizio David, Vittorio Gebbia, Teresa Gammucci, Vladimir Virz, Alessandro Lembo, Rossella Restuccia, Sebastiano Mercadante, Giampiero Porzio

Risultato della ricerca: Article

43 Citazioni (Scopus)

Abstract

Abstract CONTEXT: Existing studies on breakthrough pain (BP) have reported different prevalence rates because of different settings, populations, and assessment methods. These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated. OBJECTIVES: The aim of this study was to longitudinally assess BP in cancer patients admitted to oncology units. METHODS: A consecutive sample of patients admitted to oncology centers was selected. At admission (T0), three months after admission (T3), and six months after admission (T6), data on background pain and BP were recorded. BP was assessed in terms of its intensity, duration, number of episodes, onset with movement, spontaneous relief after stopping activity, limitation of physical activity, and effectiveness of analgesics. RESULTS: Three hundred two patients completed the study. At T0, T3, and T6, 39%, 38%, and 33% patients, respectively, had continuous pain (P=0.294). Pain intensity significantly decreased (P=0.004 and 0.027 at T3 and T6, respectively). Most patients had BP at T0 (87.1%), T3 (80.9%), and T6 (73.2%), and there was a significant decrease in the prevalence of BP over time (P=0.016). Of 149 patients with BP, pain on movement was recorded in 43.6%, 43.4%, and 32.4% at T0, T3, and T6, respectively (P=0.228). Pain spontaneously decreased or ceased when stopping physical activity in 66%, 56%, and 62% at T0, T3, and T6, respectively (P=0.537). Pain on movement strongly limited physical activity in most patients. CONCLUSION: These data expand current information about BP and underline the need for a longitudinal assessment of a phenomenon that is invariably dependent on stage of disease, patient, and therapeutic factors.
Lingua originaleEnglish
pagine (da-a)183-190
Numero di pagine8
RivistaJournal of Pain and Symptom Management
Volume40
Stato di pubblicazionePublished - 2010

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Breakthrough Pain
Longitudinal Studies
Pain
Exercise
Analgesics

All Science Journal Classification (ASJC) codes

  • Nursing(all)
  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cita questo

Casuccio, A., Gebbia, V., Arcara, C., Lanzetta, G., Breda, E., Zagonel, V., ... Porzio, G. (2010). Breakthrough pain in oncology: a longitudinal study. Journal of Pain and Symptom Management, 40, 183-190.

Breakthrough pain in oncology: a longitudinal study. / Casuccio, Alessandra; Gebbia, Vittorio; Arcara, Carlo; Lanzetta, Gaetano; Breda, Enrico; Zagonel, Vittoria; Narducci, Filomena; Aielli, Federica; Passeri, Virginia; David, Fabrizio; Gebbia, Vittorio; Gammucci, Teresa; Virz, Vladimir; Lembo, Alessandro; Restuccia, Rossella; Mercadante, Sebastiano; Porzio, Giampiero.

In: Journal of Pain and Symptom Management, Vol. 40, 2010, pag. 183-190.

Risultato della ricerca: Article

Casuccio, A, Gebbia, V, Arcara, C, Lanzetta, G, Breda, E, Zagonel, V, Narducci, F, Aielli, F, Passeri, V, David, F, Gebbia, V, Gammucci, T, Virz, V, Lembo, A, Restuccia, R, Mercadante, S & Porzio, G 2010, 'Breakthrough pain in oncology: a longitudinal study.', Journal of Pain and Symptom Management, vol. 40, pagg. 183-190.
Casuccio, Alessandra ; Gebbia, Vittorio ; Arcara, Carlo ; Lanzetta, Gaetano ; Breda, Enrico ; Zagonel, Vittoria ; Narducci, Filomena ; Aielli, Federica ; Passeri, Virginia ; David, Fabrizio ; Gebbia, Vittorio ; Gammucci, Teresa ; Virz, Vladimir ; Lembo, Alessandro ; Restuccia, Rossella ; Mercadante, Sebastiano ; Porzio, Giampiero. / Breakthrough pain in oncology: a longitudinal study. In: Journal of Pain and Symptom Management. 2010 ; Vol. 40. pagg. 183-190.
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abstract = "Abstract CONTEXT: Existing studies on breakthrough pain (BP) have reported different prevalence rates because of different settings, populations, and assessment methods. These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated. OBJECTIVES: The aim of this study was to longitudinally assess BP in cancer patients admitted to oncology units. METHODS: A consecutive sample of patients admitted to oncology centers was selected. At admission (T0), three months after admission (T3), and six months after admission (T6), data on background pain and BP were recorded. BP was assessed in terms of its intensity, duration, number of episodes, onset with movement, spontaneous relief after stopping activity, limitation of physical activity, and effectiveness of analgesics. RESULTS: Three hundred two patients completed the study. At T0, T3, and T6, 39{\%}, 38{\%}, and 33{\%} patients, respectively, had continuous pain (P=0.294). Pain intensity significantly decreased (P=0.004 and 0.027 at T3 and T6, respectively). Most patients had BP at T0 (87.1{\%}), T3 (80.9{\%}), and T6 (73.2{\%}), and there was a significant decrease in the prevalence of BP over time (P=0.016). Of 149 patients with BP, pain on movement was recorded in 43.6{\%}, 43.4{\%}, and 32.4{\%} at T0, T3, and T6, respectively (P=0.228). Pain spontaneously decreased or ceased when stopping physical activity in 66{\%}, 56{\%}, and 62{\%} at T0, T3, and T6, respectively (P=0.537). Pain on movement strongly limited physical activity in most patients. CONCLUSION: These data expand current information about BP and underline the need for a longitudinal assessment of a phenomenon that is invariably dependent on stage of disease, patient, and therapeutic factors.",
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author = "Alessandra Casuccio and Vittorio Gebbia and Carlo Arcara and Gaetano Lanzetta and Enrico Breda and Vittoria Zagonel and Filomena Narducci and Federica Aielli and Virginia Passeri and Fabrizio David and Vittorio Gebbia and Teresa Gammucci and Vladimir Virz and Alessandro Lembo and Rossella Restuccia and Sebastiano Mercadante and Giampiero Porzio",
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T1 - Breakthrough pain in oncology: a longitudinal study.

AU - Casuccio, Alessandra

AU - Gebbia, Vittorio

AU - Arcara, Carlo

AU - Lanzetta, Gaetano

AU - Breda, Enrico

AU - Zagonel, Vittoria

AU - Narducci, Filomena

AU - Aielli, Federica

AU - Passeri, Virginia

AU - David, Fabrizio

AU - Gebbia, Vittorio

AU - Gammucci, Teresa

AU - Virz, Vladimir

AU - Lembo, Alessandro

AU - Restuccia, Rossella

AU - Mercadante, Sebastiano

AU - Porzio, Giampiero

PY - 2010

Y1 - 2010

N2 - Abstract CONTEXT: Existing studies on breakthrough pain (BP) have reported different prevalence rates because of different settings, populations, and assessment methods. These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated. OBJECTIVES: The aim of this study was to longitudinally assess BP in cancer patients admitted to oncology units. METHODS: A consecutive sample of patients admitted to oncology centers was selected. At admission (T0), three months after admission (T3), and six months after admission (T6), data on background pain and BP were recorded. BP was assessed in terms of its intensity, duration, number of episodes, onset with movement, spontaneous relief after stopping activity, limitation of physical activity, and effectiveness of analgesics. RESULTS: Three hundred two patients completed the study. At T0, T3, and T6, 39%, 38%, and 33% patients, respectively, had continuous pain (P=0.294). Pain intensity significantly decreased (P=0.004 and 0.027 at T3 and T6, respectively). Most patients had BP at T0 (87.1%), T3 (80.9%), and T6 (73.2%), and there was a significant decrease in the prevalence of BP over time (P=0.016). Of 149 patients with BP, pain on movement was recorded in 43.6%, 43.4%, and 32.4% at T0, T3, and T6, respectively (P=0.228). Pain spontaneously decreased or ceased when stopping physical activity in 66%, 56%, and 62% at T0, T3, and T6, respectively (P=0.537). Pain on movement strongly limited physical activity in most patients. CONCLUSION: These data expand current information about BP and underline the need for a longitudinal assessment of a phenomenon that is invariably dependent on stage of disease, patient, and therapeutic factors.

AB - Abstract CONTEXT: Existing studies on breakthrough pain (BP) have reported different prevalence rates because of different settings, populations, and assessment methods. These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated. OBJECTIVES: The aim of this study was to longitudinally assess BP in cancer patients admitted to oncology units. METHODS: A consecutive sample of patients admitted to oncology centers was selected. At admission (T0), three months after admission (T3), and six months after admission (T6), data on background pain and BP were recorded. BP was assessed in terms of its intensity, duration, number of episodes, onset with movement, spontaneous relief after stopping activity, limitation of physical activity, and effectiveness of analgesics. RESULTS: Three hundred two patients completed the study. At T0, T3, and T6, 39%, 38%, and 33% patients, respectively, had continuous pain (P=0.294). Pain intensity significantly decreased (P=0.004 and 0.027 at T3 and T6, respectively). Most patients had BP at T0 (87.1%), T3 (80.9%), and T6 (73.2%), and there was a significant decrease in the prevalence of BP over time (P=0.016). Of 149 patients with BP, pain on movement was recorded in 43.6%, 43.4%, and 32.4% at T0, T3, and T6, respectively (P=0.228). Pain spontaneously decreased or ceased when stopping physical activity in 66%, 56%, and 62% at T0, T3, and T6, respectively (P=0.537). Pain on movement strongly limited physical activity in most patients. CONCLUSION: These data expand current information about BP and underline the need for a longitudinal assessment of a phenomenon that is invariably dependent on stage of disease, patient, and therapeutic factors.

KW - longitudinal study; breakthrough pain; cancer patients

UR - http://hdl.handle.net/10447/52268

M3 - Article

VL - 40

SP - 183

EP - 190

JO - Journal of Pain and Symptom Management

JF - Journal of Pain and Symptom Management

SN - 0885-3924

ER -