Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences neuronal plasticity throughout life.Emergence from a vegetative state (VS) after a traumatic brain injury (TBI) implies that the brain undergoesplastic changes. A common polymorphism in the BDNF gene—BDNF Val66Met (referred to herein asBDNFMet)—impairs cognitive function in healthy subjects. The aim of this study was to determine whether theBDNFMet polymorphism plays a role in the recovery of consciousness and cognitive functions in patients in a VSafter a TBI. Fifty-three patients in a VS 1 month after a TBI were included in the study and genotyped for theBDNFMet polymorphism. Scores of levels of cognitive functioning (LCF) at 1, 3, 6, and 12 months post-TBI wereretrospectively compared in patients without (Val group), and with (Met group), the BDNFMet polymorphism.The BDNFMet polymorphism was detected in 20 out of the 53 patients. The mean LCF scores in the Val and Metgroups were 1.6 – 0.5 and 1.4 – 0.5 at 1 month, 2.3 – 0.7 and 2.5 – 1.2 at 3 months, 3.3 – 1.7 and 3.5 – 1.7 at6 months, and 4 – 1.9 and 3.9 – 1.8 at 12 months, respectively ( p > 0.05). The percentages of patients in the Val andMet groups who emerged from the VS were 36.4% and 30% at 3 months, 66.3% and 70% at 6 months, and 70%and 87.5% at 12 months ( p > 0.05), respectively. These findings provide evidence that the BDNFMet polymorphismis not involved in cognitive improvement in patients with a VS following TBI. Future studies should focuson the role of other BDNF polymorphisms in the recovery from a VS.
|Numero di pagine||10|
|Rivista||Journal of Neurotrauma|
|Stato di pubblicazione||Published - 2012|