BONE MINERAL DENSITY, FRAGILITY FRACTURES AND CLINICAL RISK FACTORS

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Abstract

Osteoporosis affects the skeletal system and is characterized by a reduction in bone strength thatpredisposes one to an increased risk of fractures. In Italy, about 3.5 million women and 1 millionmen suffers from osteoporosis. These numbers are set to increase in the coming twenty yearsbecause the percentage of the Italian population over 65 will increase by 25%.The purpose of this study is to evaluate the general characteristics of a population of patientssuffering from osteoporosis and the relation with comorbidity.A single site, open-label, investigator-initiated, retrospective trial was conducted at the BoneMetabolic Disease Clinic, Department of Physical Medicine and Rehabilitation, UniversityHospital “P. Giaccone”, Palermo (Italy). 1500 patients of Bone Metabolic Diseases Clinic wereenrolled from January 2009 and September 2017.All the patients were evaluated by Hologic Discovery QDR and subjected to a questionnaire thatinvestigated general characteristics, life style, clinical data, osteoporosis pharmacological treatment,completed physical therapy, and Bone Densitometry results.The subjects with increased fracture risk have a high mean age, a lower BMI, report practicing lessphysical activity and less sun exposure. They also have a higher CIRS-comorbidity index andreport previous fragility fractures more often. The study demonstrated a statistically significantassociation between the risk of fragility fractures, T-Score ≤-1, and comorbidity.This study could contribute to develop a protocol for primary prevention of fragility fractures in thefemale population affected by osteoporosis demonstrating a correlation between comorbidity andfragility fractures incidences.
Lingua originaleEnglish
pagine (da-a)155-159
Numero di pagine5
RivistaEuroMediterranean Biomedical Journal
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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