Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma

Vito Franco, Ada Maria Florena, Claudio Tripodo, Giovanni Franco, Carla Guarnotta, Rossana Porcasi, Alessandro Gulino, Sabina Sangaletti, Barbara Frossi, Emanuela Boveri, Luca Arcaini, Pier Paolo Piccaluga, Carlo Pucillo, Mario Paolo Colombo, Elena Betto, Alice Rigoni, Stefano Aldo Pileri, Fabio Fuligni

    Risultato della ricerca: Article

    23 Citazioni (Scopus)

    Abstract

    Splenic marginal zone lymphoma (SMZL) is a mature B-cell neoplasm characterized by rather indolent clinical course. However, nearly one third of patients experience a rapidly progressive disease with a dismal outcome. Despite the characterization of clone genetics and the recognition of deregulated immunologic stimulation in the pathogenesis of SMZL, little is known about microenvironment dynamics and their potential biological influence on disease outcome. Here we investigate the effect of stroma-intrinsic features on SMZL disease progression by focusing on the microenvironment of the bone marrow (BM), which represents an elective disease localization endorsing diagnostic and prognostic relevance. We show that the quality of the BM stromal meshwork of SMZL infiltrates correlates with time to progression. In particular, we describe the unfavorable prognostic influence of dense CD40 expression by BM stromal cells, which involves the contribution of CD40 ligand (CD40L)-expressing bystander mast cells infiltrating SMZL BM aggregates. The CD40/CD40L-assisted crosstalk between mesenchymal stromal cells and mast cells populating the SMZL microenvironment finds correlation in p53(-/-) mice developing SMZL and contributes to the engendering of detrimental proinflammatory conditions. Our study highlights a dynamic interaction, playing between nonneoplastic elements within the SMZL niche, toward disease progression.
    Lingua originaleEnglish
    pagine (da-a)1836-1849
    Numero di pagine14
    RivistaBlood
    Volume123
    Stato di pubblicazionePublished - 2014

    Fingerprint

    Infiltration
    Mast Cells
    Lymphoma
    Bone
    Bone Marrow
    CD40 Ligand
    Mesenchymal Stromal Cells
    Disease Progression
    Crosstalk
    Cells
    Immunization
    B-Lymphocytes
    Clone Cells
    Neoplasms

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Cell Biology
    • Hematology
    • Biochemistry

    Cita questo

    Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma. / Franco, Vito; Florena, Ada Maria; Tripodo, Claudio; Franco, Giovanni; Guarnotta, Carla; Porcasi, Rossana; Gulino, Alessandro; Sangaletti, Sabina; Frossi, Barbara; Boveri, Emanuela; Arcaini, Luca; Piccaluga, Pier Paolo; Pucillo, Carlo; Colombo, Mario Paolo; Betto, Elena; Rigoni, Alice; Pileri, Stefano Aldo; Fuligni, Fabio.

    In: Blood, Vol. 123, 2014, pag. 1836-1849.

    Risultato della ricerca: Article

    Franco, V, Florena, AM, Tripodo, C, Franco, G, Guarnotta, C, Porcasi, R, Gulino, A, Sangaletti, S, Frossi, B, Boveri, E, Arcaini, L, Piccaluga, PP, Pucillo, C, Colombo, MP, Betto, E, Rigoni, A, Pileri, SA & Fuligni, F 2014, 'Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma', Blood, vol. 123, pagg. 1836-1849.
    Franco, Vito ; Florena, Ada Maria ; Tripodo, Claudio ; Franco, Giovanni ; Guarnotta, Carla ; Porcasi, Rossana ; Gulino, Alessandro ; Sangaletti, Sabina ; Frossi, Barbara ; Boveri, Emanuela ; Arcaini, Luca ; Piccaluga, Pier Paolo ; Pucillo, Carlo ; Colombo, Mario Paolo ; Betto, Elena ; Rigoni, Alice ; Pileri, Stefano Aldo ; Fuligni, Fabio. / Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma. In: Blood. 2014 ; Vol. 123. pagg. 1836-1849.
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    title = "Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma",
    abstract = "Splenic marginal zone lymphoma (SMZL) is a mature B-cell neoplasm characterized by rather indolent clinical course. However, nearly one third of patients experience a rapidly progressive disease with a dismal outcome. Despite the characterization of clone genetics and the recognition of deregulated immunologic stimulation in the pathogenesis of SMZL, little is known about microenvironment dynamics and their potential biological influence on disease outcome. Here we investigate the effect of stroma-intrinsic features on SMZL disease progression by focusing on the microenvironment of the bone marrow (BM), which represents an elective disease localization endorsing diagnostic and prognostic relevance. We show that the quality of the BM stromal meshwork of SMZL infiltrates correlates with time to progression. In particular, we describe the unfavorable prognostic influence of dense CD40 expression by BM stromal cells, which involves the contribution of CD40 ligand (CD40L)-expressing bystander mast cells infiltrating SMZL BM aggregates. The CD40/CD40L-assisted crosstalk between mesenchymal stromal cells and mast cells populating the SMZL microenvironment finds correlation in p53(-/-) mice developing SMZL and contributes to the engendering of detrimental proinflammatory conditions. Our study highlights a dynamic interaction, playing between nonneoplastic elements within the SMZL niche, toward disease progression.",
    author = "Vito Franco and Florena, {Ada Maria} and Claudio Tripodo and Giovanni Franco and Carla Guarnotta and Rossana Porcasi and Alessandro Gulino and Sabina Sangaletti and Barbara Frossi and Emanuela Boveri and Luca Arcaini and Piccaluga, {Pier Paolo} and Carlo Pucillo and Colombo, {Mario Paolo} and Elena Betto and Alice Rigoni and Pileri, {Stefano Aldo} and Fabio Fuligni",
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    T1 - Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma

    AU - Franco, Vito

    AU - Florena, Ada Maria

    AU - Tripodo, Claudio

    AU - Franco, Giovanni

    AU - Guarnotta, Carla

    AU - Porcasi, Rossana

    AU - Gulino, Alessandro

    AU - Sangaletti, Sabina

    AU - Frossi, Barbara

    AU - Boveri, Emanuela

    AU - Arcaini, Luca

    AU - Piccaluga, Pier Paolo

    AU - Pucillo, Carlo

    AU - Colombo, Mario Paolo

    AU - Betto, Elena

    AU - Rigoni, Alice

    AU - Pileri, Stefano Aldo

    AU - Fuligni, Fabio

    PY - 2014

    Y1 - 2014

    N2 - Splenic marginal zone lymphoma (SMZL) is a mature B-cell neoplasm characterized by rather indolent clinical course. However, nearly one third of patients experience a rapidly progressive disease with a dismal outcome. Despite the characterization of clone genetics and the recognition of deregulated immunologic stimulation in the pathogenesis of SMZL, little is known about microenvironment dynamics and their potential biological influence on disease outcome. Here we investigate the effect of stroma-intrinsic features on SMZL disease progression by focusing on the microenvironment of the bone marrow (BM), which represents an elective disease localization endorsing diagnostic and prognostic relevance. We show that the quality of the BM stromal meshwork of SMZL infiltrates correlates with time to progression. In particular, we describe the unfavorable prognostic influence of dense CD40 expression by BM stromal cells, which involves the contribution of CD40 ligand (CD40L)-expressing bystander mast cells infiltrating SMZL BM aggregates. The CD40/CD40L-assisted crosstalk between mesenchymal stromal cells and mast cells populating the SMZL microenvironment finds correlation in p53(-/-) mice developing SMZL and contributes to the engendering of detrimental proinflammatory conditions. Our study highlights a dynamic interaction, playing between nonneoplastic elements within the SMZL niche, toward disease progression.

    AB - Splenic marginal zone lymphoma (SMZL) is a mature B-cell neoplasm characterized by rather indolent clinical course. However, nearly one third of patients experience a rapidly progressive disease with a dismal outcome. Despite the characterization of clone genetics and the recognition of deregulated immunologic stimulation in the pathogenesis of SMZL, little is known about microenvironment dynamics and their potential biological influence on disease outcome. Here we investigate the effect of stroma-intrinsic features on SMZL disease progression by focusing on the microenvironment of the bone marrow (BM), which represents an elective disease localization endorsing diagnostic and prognostic relevance. We show that the quality of the BM stromal meshwork of SMZL infiltrates correlates with time to progression. In particular, we describe the unfavorable prognostic influence of dense CD40 expression by BM stromal cells, which involves the contribution of CD40 ligand (CD40L)-expressing bystander mast cells infiltrating SMZL BM aggregates. The CD40/CD40L-assisted crosstalk between mesenchymal stromal cells and mast cells populating the SMZL microenvironment finds correlation in p53(-/-) mice developing SMZL and contributes to the engendering of detrimental proinflammatory conditions. Our study highlights a dynamic interaction, playing between nonneoplastic elements within the SMZL niche, toward disease progression.

    UR - http://hdl.handle.net/10447/97449

    M3 - Article

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    JF - Blood

    SN - 0006-4971

    ER -