Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low BMI.

Maria Rosaria Bonsignore, Alice Huertas, Viviana Riti, Maria Rosaria Bonsignore, Pietro Serra, Pietro Serra, Daniela Savi, Roberta Riccioni, Paolo Palange, Ugo Testa, Pietro Serra, Eleonora Petrucci

Risultato della ricerca: Articlepeer review

43 Citazioni (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C, HGF, Ang-2, TNF-alpha, IL-6 and MCP-1 levels. Furthermore, among patients with similar pulmonary impairment, those who displayed low-BMI had a more markedly reduced number of CD34(+) cells and late endothelial progenitors. We show that the reduction in hematopoietic and endothelial progenitor cells correlates with COPD severity. Our findings also indicate that, in severe low-BMI COPD patients, bone marrow function seems to be further impaired and may lead to reduced reparative capacity.
Lingua originaleEnglish
pagine (da-a)23-31
Numero di pagine9
RivistaRESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume170
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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