TY - JOUR
T1 - Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low BMI.
AU - Bonsignore, Maria Rosaria
AU - Huertas, Alice
AU - Riti, Viviana
AU - Bonsignore, Maria Rosaria
AU - Serra, Pietro
AU - Serra, Pietro
AU - Savi, Daniela
AU - Riccioni, Roberta
AU - Palange, Paolo
AU - Testa, Ugo
AU - Serra, Pietro
AU - Petrucci, Eleonora
PY - 2010
Y1 - 2010
N2 - Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C, HGF, Ang-2, TNF-alpha, IL-6 and MCP-1 levels. Furthermore, among patients with similar pulmonary impairment, those who displayed low-BMI had a more markedly reduced number of CD34(+) cells and late endothelial progenitors. We show that the reduction in hematopoietic and endothelial progenitor cells correlates with COPD severity. Our findings also indicate that, in severe low-BMI COPD patients, bone marrow function seems to be further impaired and may lead to reduced reparative capacity.
AB - Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C, HGF, Ang-2, TNF-alpha, IL-6 and MCP-1 levels. Furthermore, among patients with similar pulmonary impairment, those who displayed low-BMI had a more markedly reduced number of CD34(+) cells and late endothelial progenitors. We show that the reduction in hematopoietic and endothelial progenitor cells correlates with COPD severity. Our findings also indicate that, in severe low-BMI COPD patients, bone marrow function seems to be further impaired and may lead to reduced reparative capacity.
KW - Chronic obstructive pulmonary disease
KW - fat-free mass
KW - low-BMI COPD
KW - normal-BMI COPD
KW - Chronic obstructive pulmonary disease
KW - fat-free mass
KW - low-BMI COPD
KW - normal-BMI COPD
UR - http://hdl.handle.net/10447/58364
M3 - Article
VL - 170
SP - 23
EP - 31
JO - RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
JF - RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
SN - 1569-9048
ER -